Biology:COP9 constitutive photomorphogenic homolog subunit 5
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COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or Csn5, is a gene conserved from humans to Saccharomyces cerevisiae.[1]
Function
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.[1]
Interactions
COP9 constitutive photomorphogenic homolog subunit 5 has been shown to interact with Macrophage migration inhibitory factor,[2][3] GFER,[4] BCL3,[5] Ubiquitin carboxy-terminal hydrolase L1,[6] S100A7[7] and C-jun.[8]
See also
- COPS1
- COPS2
- COPS3
- COPS4
- COPS6
- COPS7A
- COPS7B
- COPS8
References
- ↑ 1.0 1.1 "Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10987.
- ↑ "Interaction between parasite-encoded JAB1/CSN5 and macrophage migration inhibitory factor proteins attenuates its proinflammatory function". Scientific Reports 8 (1): 10241. July 2018. doi:10.1038/s41598-018-28625-1. PMID 29980718.
- ↑ "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1". Nature 408 (6809): 211–6. November 2000. doi:10.1038/35041591. PMID 11089976.
- ↑ "Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway". FASEB Journal 16 (1): 90–2. January 2002. doi:10.1096/fj.01-0506fje. PMID 11709497.
- ↑ "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene 18 (22): 3316–23. June 1999. doi:10.1038/sj.onc.1202717. PMID 10362352.
- ↑ "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)". Oncogene 21 (19): 3003–10. May 2002. doi:10.1038/sj.onc.1205390. PMID 12082530.
- ↑ "Psoriasin interacts with Jab1 and influences breast cancer progression". Cancer Research 63 (8): 1954–61. April 2003. PMID 12702588.
- ↑ "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors". Nature 383 (6599): 453–7. October 1996. doi:10.1038/383453a0. PMID 8837781.
External links
- Human COPS5 genome location and COPS5 gene details page in the UCSC Genome Browser.
Further reading
- "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nature Cell Biology 5 (12): 1029–33. December 2003. doi:10.1038/ncb1203-1029. PMID 14647295.
- "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors". Nature 383 (6599): 453–7. October 1996. doi:10.1038/383453a0. PMID 8837781.
- "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly". The Journal of Biological Chemistry 272 (43): 27042–52. October 1997. doi:10.1074/jbc.272.43.27042. PMID 9341143.
- "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB Journal 12 (6): 469–78. April 1998. doi:10.1096/fasebj.12.6.469. PMID 9535219.
- "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Current Biology 8 (16): 919–22. 1998. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402.
- "Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1". Nature 398 (6723): 160–5. March 1999. doi:10.1038/18230. PMID 10086358.
- "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene 18 (22): 3316–23. June 1999. doi:10.1038/sj.onc.1202717. PMID 10362352.
- "JAB1 interacts with both the progesterone receptor and SRC-1". The Journal of Biological Chemistry 275 (12): 8540–8. March 2000. doi:10.1074/jbc.275.12.8540. PMID 10722692.
- "Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity". Nature 404 (6778): 617–21. April 2000. doi:10.1038/35007098. PMID 10766246.
- "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1". Nature 408 (6809): 211–6. November 2000. doi:10.1038/35041591. PMID 11089976.
- "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". The EMBO Journal 20 (7): 1630–9. April 2001. doi:10.1093/emboj/20.7.1630. PMID 11285227.
- "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science 292 (5520): 1382–5. May 2001. doi:10.1126/science.1059780. PMID 11337588.
- "The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex". The Journal of Biological Chemistry 277 (3): 2302–10. January 2002. doi:10.1074/jbc.M104431200. PMID 11704659.
- "Jab1 interacts directly with HIF-1alpha and regulates its stability". The Journal of Biological Chemistry 277 (1): 9–12. January 2002. doi:10.1074/jbc.C100442200. PMID 11707426.
- "Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway". FASEB Journal 16 (1): 90–2. January 2002. doi:10.1096/fj.01-0506fje. PMID 11709497.
- "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer". The Journal of Biological Chemistry 277 (15): 12604–12. April 2002. doi:10.1074/jbc.M200283200. PMID 11812799.
- "Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation". EMBO Reports 3 (2): 171–6. February 2002. doi:10.1093/embo-reports/kvf024. PMID 11818334.
- "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway". Oncogene 21 (22): 3507–16. May 2002. doi:10.1038/sj.onc.1205437. PMID 12032852.
- "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)". Oncogene 21 (19): 3003–10. May 2002. doi:10.1038/sj.onc.1205390. PMID 12082530.
- "Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1". The Journal of Biological Chemistry 277 (36): 32413–6. September 2002. doi:10.1074/jbc.C200311200. PMID 12119282.
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