Biology:CRLF3
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 Generic protein structure example |
Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.[1]
Model organisms
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Normal |
| Fertility | Normal |
| Body weight | Normal |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Abnormal[2] |
| Plasma immunoglobulins | Normal |
| Haematology | Abnormal[3] |
| Peripheral blood lymphocytes | Normal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Tail epidermis wholemount | Normal |
| Skin Histopathology | Normal |
| Brain histopathology | Normal |
| Salmonella infection | Normal[4] |
| Citrobacter infection | Normal[5] |
| All tests and analysis from[6][7] |
Model organisms have been used in the study of CRLF3 function. A conditional knockout mouse line, called Crlf3tm1a(KOMP)Wtsi[8][9] was generated as part of the International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[10][11][12] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[6][13] Twenty six tests were carried out and two significant phenotypes were reported. Homozygous mutant female adults had a significant increase in circulating levels of fructosamine, while mutants of both sexes had decreased platelet cell numbers.[6]
Function
Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin receptor.[14]
Origin
Phylogenetic analyses have shown that CRLF3 at first appeared in a common ancestor of Cnidaria and Bilateria and hence emerged with the origin of the nervous system.[15][16]
References
- ↑ "Entrez Gene: cytokine receptor-like factor 3". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=51379.
- ↑ "Clinical chemistry data for Crlf3". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MADG/plasma-chemistry/.
- ↑ "Haematology data for Crlf3". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MADG/haematology-cbc/.
- ↑ "Salmonella infection data for Crlf3". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MADG/salmonella-challenge/.
- ↑ "Citrobacter infection data for Crlf3". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MADG/citrobacter-challenge/.
- ↑ 6.0 6.1 6.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
- ↑ "International Knockout Mouse Consortium". http://www.knockoutmouse.org/martsearch/search?query=Crlf3.
- ↑ "Mouse Genome Informatics". http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4363171.
- ↑ "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. June 2011. doi:10.1038/nature10163. PMID 21677750.
- ↑ "Mouse library set to be knockout". Nature 474 (7351): 262–3. June 2011. doi:10.1038/474262a. PMID 21677718.
- ↑ "A mouse for all reasons". Cell 128 (1): 9–13. January 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "The mouse genetics toolkit: revealing function and mechanism". Genome Biology 12 (6): 224. June 2011. doi:10.1186/gb-2011-12-6-224. PMID 21722353.
- ↑ "The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor" (in en). Frontiers in Molecular Neuroscience 10: 223. 2017. doi:10.3389/fnmol.2017.00223. PMID 28769759.
- ↑ "The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts". Frontiers in Molecular Neuroscience 12: 251. 2019. doi:10.3389/fnmol.2019.00251. PMID 31680856.
- ↑ "Evolution of Class I cytokine receptors". BMC Evolutionary Biology 7 (1): 120. July 2007. doi:10.1186/1471-2148-7-120. PMID 17640376.
External links
- Human CRLF3 genome location and CRLF3 gene details page in the UCSC Genome Browser.
Further reading
- "RNF135 mutations are not present in patients with Sotos syndrome-like features". American Journal of Medical Genetics. Part A 149A (4): 806–8. February 2009. doi:10.1002/ajmg.a.32694. PMID 19291764.
- "Many sequence variants affecting diversity of adult human height". Nature Genetics 40 (5): 609–15. May 2008. doi:10.1038/ng.122. PMID 18391951.
- "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature". BMC Medical Genetics 11: 96. June 2010. doi:10.1186/1471-2350-11-96. PMID 20546612.
- "Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression". The International Journal of Biochemistry & Cell Biology 41 (11): 2240–50. November 2009. doi:10.1016/j.biocel.2009.04.022. PMID 19427400.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. May 2003. doi:10.1038/nbt810. PMID 12665801.
- "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"". PLOS Genetics 6 (7): e1001016. July 2010. doi:10.1371/journal.pgen.1001016. PMID 20628624.
- "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics 7 (3): 499–508. March 2008. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
- "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nature Genetics 39 (8): 963–5. August 2007. doi:10.1038/ng2083. PMID 17632510.
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