Biology:CST11
 Generic protein structure example |
Cystatin-11 is a protein that in humans is encoded by the CST11 gene.[1]
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity.
There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions.
The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein whose specific function has not been determined. Alternative splicing yields two variants encoding distinct isoforms.[1]
References
External links
- Human CST11 genome location and CST11 gene details page in the UCSC Genome Browser.
Further reading
- "Friends and relations of the cystatin superfamily--new members and their evolution". Protein Sci. 6 (1): 5–12. 1997. doi:10.1002/pro.5560060102. PMID 9007972.
- "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". Biol. Chem. Hoppe-Seyler 369 Suppl: 191–7. 1989. PMID 3202964.
- "Genomic cloning, physical mapping, and expression of human type 2 cystatin genes". Crit. Rev. Oral Biol. Med. 4 (3–4): 573–80. 1993. doi:10.1177/10454411930040034401. PMID 7690606.
- "Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2". Genomics 24 (1): 172–5. 1995. doi:10.1006/geno.1994.1595. PMID 7896273.
- "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20". DNA Cell Biol. 13 (2): 97–116. 1994. doi:10.1089/dna.1994.13.97. PMID 8179826.
- "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "Cystatin 11: a new member of the cystatin type 2 family". Endocrinology 143 (7): 2787–96. 2002. doi:10.1210/endo.143.7.8925. PMID 12072414.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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