Biology:CTDP1
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RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.[1][2][3]
This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.[3]
Interactions
CTDP1 has been shown to interact with WD repeat-containing protein 77,[4] GTF2F1[2] and POLR2A.[5]
References
- ↑ "An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A 94 (26): 14300–5. Feb 1998. doi:10.1073/pnas.94.26.14300. PMID 9405607. Bibcode: 1997PNAS...9414300A.
- ↑ 2.0 2.1 "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J Biol Chem 273 (42): 27593–601. Nov 1998. doi:10.1074/jbc.273.42.27593. PMID 9765293.
- ↑ 3.0 3.1 "Entrez Gene: CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9150.
- ↑ Licciardo, Paolo; Amente Stefano; Ruggiero Luca; Monti Maria; Pucci Piero; Lania Luigi; Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. (England) 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMID 12560496.
- ↑ Scully, R; Anderson S F; Chao D M; Wei W; Ye L; Young R A; Livingston D M; Parvin J D (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. ISSN 0027-8424. PMID 9159119. Bibcode: 1997PNAS...94.5605S.
External links
- Human CTDP1 genome location and CTDP1 gene details page in the UCSC Genome Browser.
Further reading
- "BRCA1 is a component of the RNA polymerase II holoenzyme.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. 1997. doi:10.1073/pnas.94.11.5605. PMID 9159119. Bibcode: 1997PNAS...94.5605S.
- "Regulation of carboxyl-terminal domain phosphatase by HIV-1 tat protein.". J. Biol. Chem. 273 (48): 31726–30. 1998. doi:10.1074/jbc.273.48.31726. PMID 9822634.
- "A protein phosphatase functions to recycle RNA polymerase II.". Genes Dev. 13 (12): 1540–52. 1999. doi:10.1101/gad.13.12.1540. PMID 10385623.
- "Congenital cataracts facial dysmorphism neuropathy (CCFDN) syndrome: a novel developmental disorder in Gypsies maps to 18qter.". Eur. J. Hum. Genet. 7 (5): 560–6. 1999. doi:10.1038/sj.ejhg.5200319. PMID 10439962.
- "C-terminal domain phosphatase sensitivity of RNA polymerase II in early elongation complexes on the HIV-1 and adenovirus 2 major late templates.". J. Biol. Chem. 275 (42): 32430–7. 2000. doi:10.1074/jbc.M005898200. PMID 10938286.
- "Inhibition of Tat transactivation by the RNA polymerase II CTD-phosphatase FCP1.". AIDS 15 (3): 301–7. 2001. doi:10.1097/00002030-200102160-00002. PMID 11273209.
- "A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat.". Virology 296 (1): 6–16. 2002. doi:10.1006/viro.2002.1438. PMID 12036313.
- "Protein phosphatase-1 dephosphorylates the C-terminal domain of RNA polymerase-II.". J. Biol. Chem. 277 (43): 40442–8. 2002. doi:10.1074/jbc.M205687200. PMID 12185079.
- "FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation.". Mol. Cell. Biol. 22 (21): 7543–52. 2002. doi:10.1128/MCB.22.21.7543-7552.2002. PMID 12370301.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP.". Nucleic Acids Res. 31 (3): 999–1005. 2003. doi:10.1093/nar/gkg197. PMID 12560496.
- "Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB.". Biochemistry 42 (6): 1460–9. 2003. doi:10.1021/bi0265473. PMID 12578358.
- "The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2328–33. 2003. doi:10.1073/pnas.2628049100. PMID 12591939. Bibcode: 2003PNAS..100.2328F.
- "Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2296–9. 2003. doi:10.1073/pnas.262798199. PMID 12591941. Bibcode: 2003PNAS..100.2296K.
- "NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1.". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 5688–93. 2003. doi:10.1073/pnas.1031524100. PMID 12732728. Bibcode: 2003PNAS..100.5688N.
- "Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome.". Nat. Genet. 35 (2): 185–9. 2003. doi:10.1038/ng1243. PMID 14517542.
- "The BRCT domain is a phospho-protein binding domain.". Science 302 (5645): 639–42. 2003. doi:10.1126/science.1088753. PMID 14576433. Bibcode: 2003Sci...302..639Y.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
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