Biology:Christensenella hongkongensis
| Christensenella hongkongensis | |
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| Scientific classification | |
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| Family: | Christensenellaceae
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| Genus: | |
| Species: | C. hongkongensis
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| Binomial name | |
| Christensenella hongkongensis[1] (Lau et al. 2014) Liu et al. 2021
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Christensenella hongkongensis is a species of clinically relevant gram-positive coccobacilli, first isolated from patients in Hong Kong and Canada in 2006.[2] Although the species remains relatively rare, it has a high mortality rate of up to 50%.[3] Christensenella is thought to be broadly distributed globally, as it has been isolated from patient blood cultures around the world including Hong Kong, South Korea, New Zealand, Canada, Sweden, France and Italy. Fewer than 15 cases of C. hongkongensis have been observed worldwide.[4]
Phenotypic characteristics
C. hongkongensis grow on sheep blood agar as nonhemolytic pinpoint colonies after 48 h of incubation at 37 °C in an anaerobic environment. All are catalase positive and motile, with flagella. They produce acid from arabinose, glucose and xylose. They do not produce indole or reduce nitrate.[2]
Clinical features and diagnosis
Symptoms of C. hongkongensis infection include fever, vomiting, abdominal distension and constipation. The bacteria have been present in cases of bacteraemia.[2][5] To accurately identify C. hongkongensis, 16S rRNA sequencing is recommended.[2] Other identification methods such as MALDI-TOF, have not been able to identify the bacteria correctly.[6]
Treatment
Antibiotic treatment is usually administered upon C. hongkongensis infection. C. hongkongensis has been shown to be susceptible to antibiotics including kanamycin, vancomycin, cefuroxime, ciprofloxacin and metronidazole.[2][3] In one case, the patient recovered without any antibiotic treatment.[6]
References
- ↑ "Reclassification of Catabacter hongkongensis as Christensenella hongkongensis comb. nov. based on whole genome analysis". Int J Syst Evol Microbiol 71 (4): 4774. 2021. doi:10.1099/ijsem.0.004774. PMID 33881979.
- ↑ 2.0 2.1 2.2 2.3 2.4 Lau, S. K. P.; McNabb, A.; Woo, G. K. S.; Hoang, L.; Fung, A. M. Y.; Chung, L. M. W.; Woo, P. C. Y.; Yuen, K.-Y. (2006-11-22). "Catabacter hongkongensis gen. nov., sp. nov., Isolated from Blood Cultures of Patients from Hong Kong and Canada". Journal of Clinical Microbiology 45 (2): 395–401. doi:10.1128/jcm.01831-06. ISSN 0095-1137. PMID 17122022.
- ↑ 3.0 3.1 Lau, Susanna K. P.; Fan, Rachel Y. Y.; Lo, Hoo-Wing; Ng, Ricky H. Y.; Wong, Samson S. Y.; Li, Iris W. S.; Wu, Alan K. L.; Ng, Kenneth H. L. et al. (2012-07-01). "High Mortality Associated with Catabacter hongkongensis Bacteremia" (in en). Journal of Clinical Microbiology 50 (7): 2239–2243. doi:10.1128/JCM.00128-12. ISSN 0095-1137. PMID 22518872.
- ↑ Choi, Yong Jun; M.D; Won, Eun Jeong; M.D; Kim, Soo Hyun; M.D; Shin, Myung Geun; M.D et al. (2017-01-01). "First Case Report of Bacteremia Due to Catabacter hongkongensis in a Korean Patient" (in en). Annals of Laboratory Medicine 37 (1): 84–87. doi:10.3343/alm.2017.37.1.84. PMID 27834074.
- ↑ Elsendoorn, Antoine (July 2011). "Catabacter hongkongensis Bacteremia with Fatal Septic Shock". Emerging Infectious Diseases 17 (7): 1330–1331. doi:10.3201/eid1707.101773. ISSN 1080-6040. PMID 21762611.
- ↑ 6.0 6.1 Kaden, R.; Thelander, M.; Engstrand, L.; Herrmann, B. (2017-01-01). "First case of human bacteraemia by Catabacter hongkongensis in Scandinavia" (in en). New Microbes and New Infections 15: 6–8. doi:10.1016/j.nmni.2016.09.015. ISSN 2052-2975. PMID 27830080.
Wikidata ☰ Q62878235 entry
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