Biology:Cistrome
In simple words, the cistrome refers to a collection of regulatory elements of a set of genes, including transcription factor binding sites and histone modifications (histone acetylation, deacetylation, methylation, demethylation etc.). More specifically, "the set of cis-acting targets of a trans-acting factor on a genome-wide scale, also known as the in vivo genome-wide location of transcription factor binding sites or histone modifications".[1] The term cistrome is a portmanteau of Template:Langr (from cistron) + ome (from genome). The term cistrome was coined by investigators at the Dana–Farber Cancer Institute and Harvard Medical School.[2]
Technologies such as chromatin immunoprecipitation combined with microarray analysis "ChIP-on-chip" or with massively parallel DNA sequencing "ChIP-Seq" have greatly facilitated the definition of the cistrome of transcription factors and other chromatin associated proteins.
References
- ↑ "Cistrome: an integrative platform for transcriptional regulation studies". Genome Biol. 12 (8): R83. 2011. doi:10.1186/gb-2011-12-8-r83. PMID 21859476.
- ↑ "cistrome / FrontPage". PBWiki, Inc.. http://cistrome.pbworks.com/w/page/10521472/FrontPage.
Further reading
- "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription". Cell 132 (6): 958–70. March 2008. doi:10.1016/j.cell.2008.01.018. PMID 18358809.
- "Cistromics of hormone-dependent cancer". Endocr. Relat. Cancer 16 (2): 381–9. June 2009. doi:10.1677/ERC-09-0038. PMID 19369485.
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