Biology:CoB—CoM heterodisulfide reductase
From HandWiki
| CoB—CoM heterodisulfide reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.8.98.1 | ||||||||
| CAS number | 116515-35-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a CoB—CoM heterodisulfide reductase (EC 1.8.98.1) is an enzyme that catalyzes the chemical reaction
- coenzyme B + coenzyme M + methanophenazine N-{7-[(2-sulfoethyl)dithio]heptanoyl}-O3-phospho-L-threonine + dihydromethanophenazine
The 3 substrates of this enzyme are coenzyme B, coenzyme M, and methanophenazine, whereas its two products are N-{7-[(2-sulfoethyl)dithio]heptanoyl}-O3-phospho-L-threonine and dihydromethanophenazine.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with other, known, acceptors. The systematic name of this enzyme class is coenzyme B:coenzyme M:methanophenazine oxidoreductase. Other names in common use include heterodisulfide reductase, and soluble heterodisulfide reductase. This enzyme participates in folate biosynthesis.
References
- "Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg)". Eur. J. Biochem. 193 (1): 255–61. 1990. doi:10.1111/j.1432-1033.1990.tb19331.x. PMID 2121478.
- "Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1". J. Bacteriol. 180 (8): 2027–32. 1998. PMID 9555882.
- "Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila". Biochemistry 37 (28): 10027–39. 1998. doi:10.1021/bi9726483. PMID 9665708.
- "Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila". J. Biol. Chem. 276 (4): 2432–9. 2001. doi:10.1074/jbc.M004809200. PMID 11034998.
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