Biology:Cofrogliptin
From HandWiki
Short description: Chemical compound
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| Other names | HSK7653 |
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| Formula | C18H19F5N4O3S |
| Molar mass | 466.43 g·mol−1 |
Cofrogliptin (developmental name HSK7653) is a long-acting DPP4 inhibitor dosed once every two weeks.[1][2][3][4]
References
- ↑ Ji, Linong; Bian, Fang; Pan, Tianrong; Jiang, Hongwei; Jiang, Chengxia; Ren, Qian (20 June 2023). "55-OR: HSK7653, a Novel Ultralong-Acting DPP-4 Inhibitor, as Monotherapy in Patients With Type 2 Diabetes—A Randomized, Double-Blind, Placebo-Controlled Phase III Trial". Diabetes 72 (Supplement_1). doi:10.2337/db23-55-OR.
- ↑ Zhang, Miao; Zhang, Shudong; Yu, Zhiheng; Yao, Xueting; Lei, Zihan; Yan, Pangke; Wu, Nan; Wang, Xu et al. (October 2023). "Dose decision of HSK7653 oral immediate release tablets in specific populations clinical trials based on mechanistic physiologically-based pharmacokinetic model". European Journal of Pharmaceutical Sciences 189: 106553. doi:10.1016/j.ejps.2023.106553. PMID 37532063.
- ↑ Liu, Yang; Yan, Shuai; Liu, Jie; Liu, Hongzhong; Song, Ling; Yao, Xueting; Jiang, Ji; Li, Fangqiong et al. (May 2023). "Development and validation of an HPLC coupled with tandem mass spectrometry method for the determination of HSK7653, a novel super long‐acting dipeptidyl peptidase‐4 inhibitor, in human plasma and urine and its application to a pharmacokinetic study". Biomedical Chromatography 37 (5). doi:10.1002/bmc.5607. PMID 36802077.
- ↑ Bai, Nan; Wang, Jin; Liang, Wenxin; Gao, Leili; Cui, Wei; Wu, Qinghe; Li, Fangqiong; Ji, Linong et al. (6 November 2023). "A Multicenter, Randomized, Double-Blind, Placebo-Controlled, and Dose-Increasing Study on the Safety, Tolerability and PK/PD of Multiple Doses of HSK7653 by Oral Administration in Patients with Type 2 Diabetes Mellitus in China". Diabetes Therapy. doi:10.1007/s13300-023-01496-0. PMID 37930584.
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