Biology:Crown-rump length
Crown-rump length (CRL) is the measurement of the length of human embryos and fetuses from the top of the head (crown) to the bottom of the buttocks (rump). It is typically determined from ultrasound imagery and can be used to estimate gestational age.
Introduction
The embryo and fetus float in the amniotic fluid inside the uterus of the mother usually in a curved posture resembling the letter C. The measurement can actually vary slightly if the fetus is temporarily stretching (straightening) its body. The measurement needs to be in the natural state with an unstretched body which is actually C shaped. The measurement of CRL is useful in determining the gestational age (menstrual age starting from the first day of the last menstrual period) and thus the expected date of delivery (EDD). Different human fetuses grow at different rates and thus the gestational age is an approximation. Recent evidence has indicated that CRL growth (and thus the approximation of gestational age) may be influenced by maternal factors such as age, smoking, and folic acid intake. Early in pregnancy gestational age 8 weeks, it is accurate within about +/- 5 days but later in pregnancy due to different growth rates, the accuracy is less. In that situation, other parameters can be used in addition to CRL. The length of the umbilical cord is approximately equal to the CRL throughout pregnancy.
Gestational age is not the same as fertilization age. It takes about 14 days from the first day of the last menstrual period for conception to take place and thus for the conceptus to form. The age from this point in time (conception) is called the fertilization age and is thus 2 weeks shorter than the gestational age. Thus a 6-week gestational age would be a 4-week fertilization age. Some authorities however casually interchange these terms [citation needed] and the reader is advised to be cautious. An average gestational period (duration of pregnancy from the first day of the last menstrual period up to delivery) is 280 days. On average, this is 9 months and 6 days.
Gestational age estimation
A commonly used estimate of gestational age in weeks is (as described by Verburg et al.[2]):
[math]\displaystyle{ GA_{weeks}=CRL^{0.2313}\cdot e^{1.4653+0.001737\cdot CRL} }[/math]
| CRL (mm) | Gestational age (weeks + days) | ||
|---|---|---|---|
| 5th centile | Median | 95th centile | |
| 5 | 5 + 6 | 6 + 2 | 6 + 6 |
| 10 | 7 + 0 | 7 + 4 | 8 + 1 |
| 15 | 7 + 5 | 8 + 2 | 9 + 0 |
| 20 | 8 + 2 | 9 + 0 | 9 + 5 |
| 25 | 8 + 6 | 9 + 4 | 10 + 2 |
| 30 | 9 + 2 | 10 + 0 | 10 + 6 |
| 35 | 9 + 5 | 10 + 3 | 11 + 2 |
| 40 | 10 + 1 | 10 + 6 | 11 + 5 |
| 45 | 10 + 3 | 11 + 2 | 12 + 1 |
| 50 | 10 + 6 | 11 + 5 | 12 + 4 |
| 55 | 11 + 1 | 12 + 0 | 13 + 0 |
| 60 | 11 + 3 | 12 + 3 | 13 + 3 |
| 65 | 11 + 6 | 12 + 5 | 13 + 5 |
| 70 | 12 + 1 | 13 + 0 | 14 + 0 |
| 75 | 12 + 3 | 13 + 3 | 14 + 3 |
| 80 | 12 + 5 | 13 + 5 | 14 + 5 |
| 85 | 13 + 0 | 14 + 0 | 15 + 1 |
| 90 | 13 + 2 | 14 + 2 | 15 + 3 |
| 95 | 13 + 4 | 14 + 4 | 15 + 5 |
| 100 | 13 + 6 | 15 + 0 | 16 + 1 |
Gestational age estimation in days is carried out according to the equations:
[math]\displaystyle{ GA_{days}=40.9+3.24585\cdot CRL^{0.5}+0.348956\cdot CRL }[/math] ; and SD of GA = 2.39102 + (0.0193474 × CRL).
See also
References
- ↑ "Estimation of gestational age in early pregnancy from crown-rump length when gestational age range is truncated: the case study of the INTERGROWTH-21st Project". BMC Medical Research Methodology 13: 151. December 2013. doi:10.1186/1471-2288-13-151. PMID 24314232.
Crown rump length before a gestational age of 9 weeks is extrapolated by assuming a crown rump length of 0 at a gestational age of 2 weeks, corresponding to an embryonic age of 0 weeks. This extrapolated part is blurred because of uncertain values. - ↑ 2.0 2.1 "New charts for ultrasound dating of pregnancy and assessment of fetal growth: longitudinal data from a population-based cohort study". Ultrasound in Obstetrics & Gynecology 31 (4): 388–96. April 2008. doi:10.1002/uog.5225. PMID 18348183.
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