Biology:DACH2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Dachshund homolog 2 is a protein that in humans is encoded by the DACH2 gene.

Function

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure.

Further reading

• "Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B". Human Reproduction 19 (12): 2759–66. Dec 2004. doi:10.1093/humrep/deh502. PMID 15459172. 
• "In vivo characterization of a vertebrate ultraconserved enhancer". Genomics 85 (6): 774–81. Jun 2005. doi:10.1016/j.ygeno.2005.03.003. PMID 15885503. https://digital.library.unt.edu/ark:/67531/metadc781152/. 
• "Characterization of mouse Dach2, a homologue of Drosophila dachshund". Mechanisms of Development 102 (1–2): 169–79. Apr 2001. doi:10.1016/s0925-4773(01)00307-0. PMID 11287190. 
• "Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation". The EMBO Journal 25 (17): 3955–65. Sep 2006. doi:10.1038/sj.emboj.7601273. PMID 16917507. 
• "Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes". Cytogenetic and Genome Research 97 (1–2): 32–8. 2002. doi:10.1159/000064052. PMID 12438735.