Biology:dATP(dGTP)—DNA purinetransferase
From HandWiki
| dATP(dGTP)—DNA purinetransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.6.99.1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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dATP(dGTP)—DNA purinetransferase (EC 2.6.99.1) is an enzyme with systematic name dATP(dGTP):depurinated-DNA purine transferase.[1][2] This enzyme catalyses the following chemical reaction
- (1) dATP + depurinated DNA [math]\displaystyle{ \rightleftharpoons }[/math] deoxyribose triphosphate + DNA
- (2) dGTP + depurinated DNA [math]\displaystyle{ \rightleftharpoons }[/math] deoxyribose triphosphate + DNA
The purine residue is transferred on to the apurinic site forming a normal glycosylic bond.
References
- ↑ "DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites". Proceedings of the National Academy of Sciences of the United States of America 76 (1): 141–4. January 1979. doi:10.1073/pnas.76.1.141. PMID 218192. Bibcode: 1979PNAS...76..141D.
- ↑ "Enzymatic insertion of purine bases into depurinated DNA in vitro". Proceedings of the National Academy of Sciences of the United States of America 76 (3): 1089–93. March 1979. doi:10.1073/pnas.76.3.1089. PMID 375225. Bibcode: 1979PNAS...76.1089L.
External links
- DATP(dGTP)---DNA+purinetransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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