Biology:DCLK1
From HandWiki
Doublecortin-like kinase protein 1 (DCLK1)[1][2][3][4] is an enzyme that in humans is encoded by the DCLK1 gene.[1][2][4] Its C-terminal domain in rats is expressed independently from an alternative transcript, cpg16, and can function alone as a serine/threonine protein kinase that is cyclic AMP dependent.[5][6]
DCLK1 expression is a marker for tuft cells, a type of chemosensory cell of the intestinal epithelium.[3][7]
References
- ↑ 1.0 1.1 "Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin". J Hum Genet 43 (3): 169–77. Oct 1998. doi:10.1007/s100380050063. PMID 9747029.
- ↑ 2.0 2.1 "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)". Genomics 56 (1): 121–6. May 1999. doi:10.1006/geno.1998.5718. PMID 10036192.
- ↑ 3.0 3.1 "DCLK1 and tuft cells: Immune-related functions and implications for cancer immunotherapy". Critical Reviews in Oncology and Hematology 191. 2023. doi:10.1016/j.critrevonc.2023.104118. PMID 37660932.
- ↑ 4.0 4.1 "Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1". National Library of Medicine. 7 April 2024. https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9201.
- ↑ "CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase". Journal of Biological Chemistry 274 (5): 2631–2636. 1999. doi:10.1074/jbc.274.5.2631. PMID 9915791.
- ↑ "DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization.". J. Neurosci. 20 (24): 9152–61. 2001. doi:10.1523/JNEUROSCI.20-24-09152.2000. PMID 11124993.
- ↑ "The intestinal epithelium tuft cells: specification and function". Cellular and Molecular Life Sciences 69 (17): 2907–2917. 2012. doi:10.1007/s00018-012-0984-7. PMID 22527717.
Further reading
- "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. 1997. doi:10.1093/dnares/4.2.141. PMID 9205841.
- "Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS).". Genomics 56 (2): 179–83. 1999. doi:10.1006/geno.1998.5673. PMID 10051403.
- "Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities.". J. Biol. Chem. 277 (20): 17696–705. 2002. doi:10.1074/jbc.M111981200. PMID 11884394.
- "Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase.". Acta Crystallogr. D 59 (Pt 3): 502–5. 2003. doi:10.1107/S0907444903000027. PMID 12595708. Bibcode: 2003AcCrD..59..502K.
- "The DCX-domain tandems of doublecortin and doublecortin-like kinase.". Nat. Struct. Biol. 10 (5): 324–33. 2003. doi:10.1038/nsb918. PMID 12692530.
- "Endofin recruits TOM1 to endosomes.". J. Biol. Chem. 279 (6): 4670–9. 2004. doi:10.1074/jbc.M311228200. PMID 14613930.
- "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell. Proteomics 3 (11): 1093–101. 2005. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
External links
- Overview of all the structural information available in the PDB for UniProt: O15075 (Serine/threonine-protein kinase DCLK1) at the PDBe-KB.
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