Biology:DDX21
 Generic protein structure example |
Nucleolar RNA helicase 2 is an enzyme that in humans is encoded by the DDX21 gene.[1][2]
Function
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.[2]
Interactions
DDX21 has been shown to interact with C-jun.[3]
References
- ↑ "A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease". Nucleic Acids Res. 24 (7): 1220–4. Jun 1996. doi:10.1093/nar/24.7.1220. PMID 8614622.
- ↑ 2.0 2.1 "Entrez Gene: DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9188.
- ↑ "The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription". EMBO J. 21 (3): 451–60. Feb 2002. doi:10.1093/emboj/21.3.451. PMID 11823437.
Further reading
- "Cloning and characterization of Gu/RH-II binding protein". Biochem. Biophys. Res. Commun. 234 (2): 335–40. 1997. doi:10.1006/bbrc.1997.6642. PMID 9177271.
- "Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression". Genomics 66 (2): 184–94. 2000. doi:10.1006/geno.2000.6209. PMID 10860663.
- "Human RNA helicase II/Gu gene: genomic organization and promoter analysis". Biochem. Biophys. Res. Commun. 281 (4): 1006–11. 2001. doi:10.1006/bbrc.2001.4446. PMID 11237763.
- "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- "The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription". EMBO J. 21 (3): 451–60. 2002. doi:10.1093/emboj/21.3.451. PMID 11823437.
- "Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs". Gene 284 (1–2): 53–61. 2002. doi:10.1016/S0378-1119(01)00888-5. PMID 11891046.
- "Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production". J. Biol. Chem. 278 (52): 52307–14. 2003. doi:10.1074/jbc.M310846200. PMID 14559904.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413.
- "Functional interaction between RNA helicase II/Gu(alpha) and ribosomal protein L4". FEBS J. 272 (15): 3788–802. 2005. doi:10.1111/j.1742-4658.2005.04811.x. PMID 16045751.
- "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. 2006. doi:10.1073/pnas.0507066103. PMID 16565220.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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