Biology:DDX39
 Generic protein structure example |
ATP-dependent RNA helicase DDX39 is an enzyme that in humans is encoded by the DDX39 gene.[1][2]
This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.[2]
References
- ↑ "The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family". Genomics 26 (2): 210–8. Aug 1995. doi:10.1016/0888-7543(95)80203-X. PMID 7601445.
- ↑ 2.0 2.1 "Entrez Gene: DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10212.
Further reading
- "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- "TREX is a conserved complex coupling transcription with messenger RNA export.". Nature 417 (6886): 304–8. 2002. doi:10.1038/nature746. PMID 11979277.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. 2004. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56.". Nucleic Acids Res. 32 (6): 1857–65. 2004. doi:10.1093/nar/gkh347. PMID 15047853.
- "Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function.". Cell. Mol. Life Sci. 61 (17): 2264–73. 2004. doi:10.1007/s00018-004-4205-x. PMID 15338056.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49.". Gene 384: 37–44. 2007. doi:10.1016/j.gene.2006.07.010. PMID 16949217.
- "Intracellular characterization of DDX39, a novel growth-associated RNA helicase.". Exp. Cell Res. 313 (4): 782–90. 2007. doi:10.1016/j.yexcr.2006.11.014. PMID 17196963.
- "Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.". Mol. Biol. Cell 24 (8): 1208–21. 2013. doi:10.1091/mbc.E12-06-0450. PMID 23427269.
External links
- DDX39A human gene location in the UCSC Genome Browser.
- DDX39A human gene details in the UCSC Genome Browser.
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