Biology:DHR1 domain
From HandWiki
DHR1 (DOCK homology region 1), also known as CZH1 or Docker1, is a protein domain of approximately 200–250 amino acids that is present in the DOCK family of signalling proteins.[1] This domain binds phospholipids and so may assist in recruitment to cellular membranes.[2] There is evidence that this domain may also mediate protein–protein interactions.[3]
References
- ↑ "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937–46. November 2005. doi:10.1242/jcs.02671. PMID 16254241.
- ↑ "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling". Nat. Cell Biol. 7 (8): 797–807. August 2005. doi:10.1038/ncb1280. PMID 16025104.
- ↑ Hara S; Kiyokawa E; Iemura SI et al. (July 2008). "The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport". Mol. Biol. Cell 19 (9): 3823–35. doi:10.1091/mbc.E08-03-0314. PMID 18596235.
Further reading
- "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell Sci. 115 (Pt 24): 4901–13. 2002. doi:10.1242/jcs.00219. PMID 12432077.
- "GEF what? Dock180 and related proteins help Rac to polarize cells in new ways". Trends Cell Biol. 17 (8): 383–93. 2007. doi:10.1016/j.tcb.2007.05.001. PMID 17765544.
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