Biology:DIP2A
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Disco-interacting protein 2 homolog A is a protein that in humans is encoded by the DIP2A gene.[1]
Model organisms
Model organisms have been used in the study of DIP2A function. A conditional knockout mouse line called Dip2atm2b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[2] Male and female animals underwent a standardized phenotypic screen[3] to determine the effects of deletions.[4][5][6][7] Additional screens performed: - In-depth immunological phenotyping[8]
| Characteristic | Phenotype |
|---|---|
| All data available at.[3][8] | |
| Peripheral blood leukocytes 6 Weeks | Normal |
| Haematology 6 Weeks | Normal |
| Insulin | Normal |
| Homozygous viability at P14 | Normal |
| Homozygous Fertility | Normal |
| Body weight | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Abnormal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology 16 Weeks | Normal |
| Peripheral blood leukocytes 16 Weeks | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Cytotoxic T Cell Function | Normal |
| Spleen Immunophenotyping | Normal |
| Mesenteric Lymph Node Immunophenotyping | Normal |
| Bone Marrow Immunophenotyping | Normal |
| Anti-nuclear Antibody Assay | Normal |
| Epidermal Immune Composition | Normal |
| Influenza Challenge | Normal |
.
See also
- DIP2B
- DIP2C
References
- ↑ "Entrez Gene: DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23181.
- ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ 3.0 3.1 "International Mouse Phenotyping Consortium". http://www.mousephenotype.org/data/search?q=Dip2a#fq=*:*&facet=gene.
- ↑ "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. Jun 2011. doi:10.1038/nature10163. PMID 21677750.
- ↑ "Mouse library set to be knockout". Nature 474 (7351): 262–3. Jun 2011. doi:10.1038/474262a. PMID 21677718.
- ↑ "A mouse for all reasons". Cell 128 (1): 9–13. Jan 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. 2013. doi:10.1016/j.cell.2013.06.022. PMID 23870131.
- ↑ 8.0 8.1 "Infection and Immunity Immunophenotyping (3i) Consortium". http://www.immunophenotyping.org/data/search?keys=Dip2a&field_gene_construct_tid=All.
Further reading
- "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. 1996. doi:10.1093/dnares/3.1.17. PMID 8724849.
- "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins.". Brain Res. Dev. Brain Res. 130 (2): 217–30. 2002. doi:10.1016/S0165-3806(01)00239-5. PMID 11675124.
- "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2.". J. Biol. Chem. 277 (15): 12622–31. 2002. doi:10.1074/jbc.M110568200. PMID 11812785.
- "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.". Genomics 79 (6): 833–43. 2002. doi:10.1006/geno.2002.6782. PMID 12036298.
- "Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.". Gene 293 (1–2): 59–65. 2002. doi:10.1016/S0378-1119(02)00694-7. PMID 12137943.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs.". Gene 321: 185–93. 2004. doi:10.1016/S0378-1119(03)00835-7. PMID 14637006.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.". Am. J. Hum. Genet. 80 (2): 221–31. 2007. doi:10.1086/510800. PMID 17236128.
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