Biology:DIS3

From HandWiki

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene.[1][2] Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.[3][4]

References

  1. "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Hum Genet 110 (2): 111–21. Apr 2002. doi:10.1007/s00439-001-0646-6. PMID 11935316. https://zenodo.org/record/1232709. 
  2. "Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3". J Biochem 123 (5): 883–90. Jul 1998. doi:10.1093/oxfordjournals.jbchem.a022020. PMID 9562621. 
  3. "Entrez Gene: DIS3 DIS3 mitotic control homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=22894. 
  4. Tomecki, R.; Kristiansen, MS; Lykke-Andersen, S; Chlebowski, A; Larsen, KM; Szczesny, RJ; Drazkowska, K; Pastula, A et al. (2010). "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L". The EMBO Journal 29 (14): 2342–57. doi:10.1038/emboj.2010.121. PMID 20531386. 

Further reading