Biology:DLEU1
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In molecular biology, deleted in lymphocytic leukemia 1 (non-protein coding), also known as DLEU1, is a long non-coding RNA. In humans it is located on chromosome 13q14. The DLEU1 gene was originally identified as a potential tumour suppressor gene and is often deleted in patients with B-cell chronic lymphocytic leukemia.[1] It was later discovered to be a long non-coding RNA with over 20 different splice variants.[2]
See also
- Long noncoding RNA
References
- ↑ "Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia". Oncogene 15 (20): 2463–2473. Nov 1997. doi:10.1038/sj.onc.1201643. PMID 9395242.
- ↑ "B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions". Human Molecular Genetics 10 (12): 1275–1285. Jun 2001. doi:10.1093/hmg/10.12.1275. PMID 11406609.
Further reading
- "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–968. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14". Genomics 70 (3): 327–334. Dec 2000. doi:10.1006/geno.2000.6386. PMID 11161783.
- "Chronic lymphocytic leukemia and 13q14: miRs and more". Leukemia & Lymphoma 50 (3): 502–505. Mar 2009. doi:10.1080/10428190902763509. PMID 19347735.
- "Genome-wide association study of anthropometric traits in Korcula Island, Croatia". Croatian Medical Journal 50 (1): 7–16. Feb 2009. doi:10.3325/cmj.2009.50.7. PMID 19260139.
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