Biology:DPP7
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene.[1][2][3]
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolyl carboxypeptidase and is active at both acidic and neutral pH.[3]
References
- ↑ "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase". J Immunol 163 (6): 3092–9. Oct 1999. doi:10.4049/jimmunol.163.6.3092. PMID 10477574.
- ↑ "Cloning and functional expression of rat kidney dipeptidyl peptidase II". Biochem J 353 (Pt 2): 283–90. Jan 2001. doi:10.1042/0264-6021:3530283. PMID 11139392.
- ↑ 3.0 3.1 "Entrez Gene: DPP7 dipeptidyl-peptidase 7". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=29952.
Further reading
- "Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells". Histol. Histopathol. 7 (2): 163–8. 1992. PMID 1515698.
- "The effect of antimitotic agents on the intraneuronal distribution of lysosomes". Brain Res. 521 (1–2): 62–72. 1990. doi:10.1016/0006-8993(90)91525-L. PMID 2207678.
- "Lysosomal heterogeneity of dipeptidyl peptidase II active on collagen-related peptides". Ren. Physiol. Biochem. 12 (1): 32–40. 1989. doi:10.1159/000173177. PMID 2727382.
- Demuth HU; Schlenzig D; Schierhorn A; Grosche, G; Chapotchartier, M; Gripon, J (1993). "Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases". FEBS Lett. 320 (1): 23–7. doi:10.1016/0014-5793(93)81649-K. PMID 8096464.
- Underwood R; Chiravuri M; Lee H; Schmitz, T; Kabcenell, AK; Yardley, K; Huber, BT (1999). "Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase". J. Biol. Chem. 274 (48): 34053–8. doi:10.1074/jbc.274.48.34053. PMID 10567372.
- Chiravuri M; Agarraberes F; Mathieu SL; Lee, H; Huber, BT (2000). "Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase". J. Immunol. 165 (10): 5695–702. doi:10.4049/jimmunol.165.10.5695. PMID 11067927.
- Araki H; Li Y; Yamamoto Y; Haneda, M; Nishi, K; Kikkawa, R; Ohkubo, I (2001). "Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase". J. Biochem. 129 (2): 279–88. doi:10.1093/oxfordjournals.jbchem.a002855. PMID 11173530.
- Zhan H; Yamamoto Y; Shumiya S; Kunimatsu, Mitoshi; Nishi, Katsuji; Ohkubo, Iwao; Kani, Kazutaka (2002). "Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats". Histochem. J. 33 (9–10): 511–21. doi:10.1023/A:1014943522613. PMID 12005022.
- Strausberg RL; Feingold EA; Grouse LH; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Leiting B; Pryor KD; Wu JK; Marsilio, Frank; Patel, Reshma A.; Craik, Charles S.; Ellman, Jonathan A.; Cummings, Richard T. et al. (2003). "Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII". Biochem. J. 371 (Pt 2): 525–32. doi:10.1042/BJ20021643. PMID 12529175.
- "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. 2004. doi:10.1101/gr.2122004. PMID 15231747.
- Gerhard DS; Wagner L; Feingold EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
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