Biology:DUSP10
 Generic protein structure example |
Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.[1][2][3]
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.[3]
Interactions
DUSP10 has been shown to interact with MAPK14[4][5][6] and MAPK8.[1]
References
- ↑ 1.0 1.1 "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J Biol Chem 274 (28): 19949–56. Aug 1999. doi:10.1074/jbc.274.28.19949. PMID 10391943.
- ↑ "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases". Oncogene 18 (50): 6981–8. Jan 2000. doi:10.1038/sj.onc.1203185. PMID 10597297.
- ↑ 3.0 3.1 "Entrez Gene: DUSP10 dual specificity phosphatase 10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11221.
- ↑ Tanoue, T; Moriguchi T; Nishida E (Jul 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J. Biol. Chem. (UNITED STATES) 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. ISSN 0021-9258. PMID 10391943.
- ↑ Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. (United States) 276 (28): 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773.
- ↑ Tanoue, T; Maeda R; Adachi M; Nishida E (Feb 2001). "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. (England) 20 (3): 466–79. doi:10.1093/emboj/20.3.466. ISSN 0261-4189. PMID 11157753.
Further reading
- "The "VH1-like" dual-specificity protein tyrosine phosphatases.". Mol. Cells 8 (1): 2–11. 1998. doi:10.1016/S1016-8478(23)13385-1. PMID 9571625.
- "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress.". J. Biol. Chem. 282 (39): 28395–407. 2007. doi:10.1074/jbc.M705142200. PMID 17681939.
- "Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5.". Protein Sci. 16 (5): 880–6. 2007. doi:10.1110/ps.062712807. PMID 17400920.
- "Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells.". Carcinogenesis 28 (6): 1188–96. 2007. doi:10.1093/carcin/bgl241. PMID 17151092.
- "Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase.". J. Mol. Biol. 360 (5): 946–55. 2006. doi:10.1016/j.jmb.2006.05.059. PMID 16806267.
- "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.". J. Biol. Chem. 276 (28): 26629–39. 2001. doi:10.1074/jbc.M101981200. PMID 11359773.
- "Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10.". Cytogenet. Cell Genet. 90 (1–2): 71–4. 2000. doi:10.1159/000015666. PMID 11060451.
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