Biology:ENTPD5
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Ectonucleoside triphosphate diphosphohydrolase 5 is an enzyme that in humans is encoded by the ENTPD5 gene.[1][2][3]
ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.[3]
References
- ↑ "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm Genome 8 (9): 668–72. Oct 1997. doi:10.1007/s003359900534. PMID 9271669.
- ↑ "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics 50 (3): 357–67. Oct 1998. doi:10.1006/geno.1998.5317. PMID 9676430.
- ↑ 3.0 3.1 "Entrez Gene: ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=957.
Further reading
- "CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates". J. Biol. Chem. 274 (29): 20064–7. 1999. doi:10.1074/jbc.274.29.20064. PMID 10400613.
- Recio JA; Zambrano N; Peña L et al. (2000). "The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells". Mol. Carcinog. 27 (3): 229–36. doi:10.1002/(SICI)1098-2744(200003)27:3<229::AID-MC10>3.0.CO;2-Z. PMID 10708485.
- Mulero JJ; Yeung G; Nelken ST et al. (2000). "Biochemical characterization of CD39L4". Biochemistry 39 (42): 12924–8. doi:10.1021/bi000960y. PMID 11041857.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Blánquez MJ; Regadera J; Mariño J et al. (2003). "Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia". Mol. Carcinog. 35 (4): 186–95. doi:10.1002/mc.10091. PMID 12489110.
- "Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase". Biochim. Biophys. Acta 1747 (2): 251–9. 2005. doi:10.1016/j.bbapap.2004.11.017. PMID 15698960.
- Liu T; Qian WJ; Gritsenko MA et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
- Regadera J; Blánquez MJ; González-Peramato P et al. (2006). "PCPH expression is an early event in the development of testicular germ cell tumors". Int. J. Oncol. 28 (3): 595–604. doi:10.3892/ijo.28.3.595. PMID 16465363.
- Villar J; Arenas MI; MacCarthy CM et al. (2007). "PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism". Cancer Res. 67 (22): 10859–68. doi:10.1158/0008-5472.CAN-07-2041. PMID 18006831.
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