Biology:ERH (gene)
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
| Enhancer of rudimentary | |||||||||
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 crystal structure of enhancer of rudimentary homologue (erh) | |||||||||
| Identifiers | |||||||||
| Symbol | ER | ||||||||
| Pfam | PF01133 | ||||||||
| InterPro | IPR000781 | ||||||||
| PROSITE | PDOC00732 | ||||||||
| SCOP2 | 1j24 / SCOPe / SUPFAM | ||||||||
| TCDB | 3.A.16 | ||||||||
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In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene.[1][2][3]
The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis.[4]
From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms.[2] It has been proposed that this protein plays a role in the cell cycle.
References
- ↑ "Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene". Genomics 32 (1): 125–7. Sep 1996. doi:10.1006/geno.1996.0086. PMID 8786099.
- ↑ 2.0 2.1 "The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals". Gene 186 (2): 189–95. Apr 1997. doi:10.1016/S0378-1119(96)00701-9. PMID 9074495.
- ↑ "Entrez Gene: ERH enhancer of rudimentary homolog (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2079.
- ↑ Wojcik, E.; Murphy, A. M.; Fares, H.; Dang-Vu, K.; Tsubota, S. I. (1994). "Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene". Genetics 138 (4): 1163–1170. doi:10.1093/genetics/138.4.1163. PMID 7896098.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. 2005. doi:10.1016/j.febslet.2004.12.045. PMID 15670829.
- "Structure of the conserved transcriptional repressor enhancer of rudimentary homolog". Biochemistry 44 (13): 5017–23. 2005. doi:10.1021/bi047785w. PMID 15794639.
- "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070. http://edoc.mpg.de/get.epl?fid=21592&did=275687&ver=0.
- "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks". Proteins 68 (2): 427–37. 2007. doi:10.1002/prot.21343. PMID 17444515.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Enhancer of rudimentary homolog (ERH)
- PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Enhancer of rudimentary homolog (ERH)
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