Biology:EVI5
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Ecotropic viral integration site 5 protein homolog is a protein that in humans is encoded by the EVI5 gene.[1][2]
Model organisms
Model organisms have been used in the study of EVI5 function. A conditional knockout mouse line called Evi5tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]
| Characteristic | Phenotype |
|---|---|
| All data available at.[4][9] | |
| Peripheral blood leukocytes 6 Weeks | Normal |
| Insulin | Normal |
| Haematology 6 Weeks | Normal |
| Homozygous viability at P14 | Normal |
| Homozygous Fertility | Normal |
| Body weight | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology 16 Weeks | Normal |
| Peripheral blood leukocytes 16 Weeks | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Cytotoxic T Cell Function | Normal |
| Spleen Immunophenotyping | Normal |
| Mesenteric Lymph Node Immunophenotyping | Normal |
| Bone Marrow Immunophenotyping | Normal |
| Epidermal Immune Composition | Normal |
References
- ↑ "NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma". Human Molecular Genetics 7 (7): 1169–78. Jul 1998. doi:10.1093/hmg/7.7.1169. PMID 9618176.
- ↑ "Entrez Gene: EVI5 ecotropic viral integration site 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7813.
- ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ 4.0 4.1 "International Mouse Phenotyping Consortium". http://www.mousephenotype.org/data/search?q=Evi5#fq=*:*&facet=gene.
- ↑ "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. Jun 2011. doi:10.1038/nature10163. PMID 21677750.
- ↑ "Mouse library set to be knockout". Nature 474 (7351): 262–3. Jun 2011. doi:10.1038/474262a. PMID 21677718.
- ↑ "A mouse for all reasons". Cell 128 (1): 9–13. Jan 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. Jul 2013. doi:10.1016/j.cell.2013.06.022. PMID 23870131.
- ↑ 9.0 9.1 "Infection and Immunity Immunophenotyping (3i) Consortium". http://www.immunophenotyping.org/data/search?keys=Evi5&field_gene_construct_tid=All.
Further reading
- "The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11". Oncogene 26 (19): 2804–8. Apr 2007. doi:10.1038/sj.onc.1210081. PMID 17099728.
- "Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene". Proceedings of the National Academy of Sciences of the United States of America 104 (4): 1236–41. Jan 2007. doi:10.1073/pnas.0610500104. PMID 17229837. Bibcode: 2007PNAS..104.1236W.
- "EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis". Experimental Cell Research 312 (12): 2325–35. Jul 2006. doi:10.1016/j.yexcr.2006.03.032. PMID 16764853.
- "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. Apr 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1". Cell 124 (2): 367–80. Jan 2006. doi:10.1016/j.cell.2005.10.038. PMID 16439210.
- "EVI5 is a novel centrosomal protein that binds to alpha- and gamma-tubulin". Genomics 86 (5): 594–605. Nov 2005. doi:10.1016/j.ygeno.2005.06.002. PMID 16033705.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. Jun 2004. doi:10.1038/nbt971. PMID 15146197.
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