Biology:Ecdysteroid
Ecdysteroids are arthropod steroid hormones that are mainly responsible for molting, development and, to a lesser extent, reproduction;[1][2][3] examples of ecdysteroids include ecdysone, ecdysterone, turkesterone and 2-deoxyecdysone.[4] These compounds are synthesized in arthropods from dietary cholesterol upon metabolism by the Halloween family of cytochrome P450s.[5] Phytoecdysteroids also appear in many plants mostly as a protection agents (toxins or antifeedants) against herbivore insects.[6][7]
Ecdysterone has been tested on mammals due to the interest in its potential hypertrophic effect. It has been found to increase hypertrophy in rats at a similar level to some anabolic androgenic steroids and SARM S 1.[8] This is proposed to be through increase of Calcium leading to activation of Akt and protein synthesis in skeletal muscles.[9]
See also
External links
- Ecdybase, The Ecdysone Handbook - a free online ecdysteroids database
References
- ↑ "Ecdysteroids: the overlooked sex steroids of insects? Males: the black box". Insect Science 13 (5): 325–338. 2006. doi:10.1111/j.1744-7917.2006.00101.x. Bibcode: 2006InsSc..13..325D.
- ↑ "Control of molting in mandibulate and chelicerate arthropods by ecdysones". The Biological Bulletin 139 (3): 520–538. December 1970. doi:10.2307/1540371. PMID 5494238. https://www.biodiversitylibrary.org/part/24248.
- ↑ "Ecdysteroid titers and developmental expression of ecdysteroid-regulated genes during metamorphosis of the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae)". Journal of Insect Physiology 52 (6): 558–568. June 2006. doi:10.1016/j.jinsphys.2006.02.003. PMID 16580015.
- ↑ "Ecdysteroids Information". Examine.com. http://examine.com/supplements/Ecdysteroids/.
- ↑ "Ecdysteroid metabolism in crustaceans". The Journal of Steroid Biochemistry and Molecular Biology 127 (3–5): 196–203. November 2011. doi:10.1016/j.jsbmb.2010.09.001. PMID 20837145.
- ↑ "Phytoecdysteroids: biological aspects". Phytochemistry 57 (3): 325–339. June 2001. doi:10.1016/S0031-9422(01)00078-4. PMID 11393511.
- ↑ "On the distribution of phytoecdysteroids in plants". Cellular and Molecular Life Sciences 58 (8): 1121–1132. July 2001. doi:10.1007/PL00000926. PMID 11529504.
- ↑ "Ecdysteroids: A novel class of anabolic agents?". Biology of Sport 32 (2): 169–173. June 2015. doi:10.5604/20831862.1144420. PMID 26060342.
- ↑ "Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cells". Steroids 75 (10): 632–637. October 2010. doi:10.1016/j.steroids.2010.03.008. PMID 20363237.
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