Biology:Electrophysiological techniques for clinical diagnosis

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Short description: Clinical diagnosis using electrical signals
Electrophysiological techniques for clinical diagnosis
Medical diagnostics
PurposeAscertain electrical signals from the human body for diagnosis

Clinical Electrophysiological Testing is based on techniques derived from electrophysiology used for the clinical diagnosis of patients. There are many processes that occur in the body which produce electrical signals that can be detected. Depending on the location and the source of these signals, distinct methods and techniques have been developed to properly target them.

Role of electrophysiology in clinical medicine

Electrophysiology has a very important role in ensuring accurate clinical diagnoses. The brain, the heart and skeletal muscles are prime sources of electric and magnetic fields that can be recorded and the resulting patterns can give insight on what ailments the subject may have.

While electrophysiological tests generally passively collect electrical data, it is sometimes necessary to apply an external stimulus to the desired target in order to produce transient evoked potentials that can provide further insight not obtained from solely passive recording methods.

Electroencephalography (EEG)

Electroencephalography is the measurement of brain activity through the surface of the scalp.[1] Electroencephalography data can be viewed as a qualitative wave form, or it can be further processed through analytical procedures to produce quantitative electroencephalography (qEEG).[2] If qEEG data is mapped from multiple parts of the brain then it is a topographic qEEG (also known as brain electrical activity mapping or BEAM).

If EEGs are recorded after intentionally stimulating the brain, then the resulting data is called a event related potential. The firing of neurons throughout the brain has been known to have localized relationships to certain functions, processes and reactions to stimuli. With proper equipment it is possible to locate where in the brain neurons have been activated and measure their event related potentials. Event-related potentials can be classified as either: sensory, motor or cognitive.[3]

EEGs can be used to diagnose and monitor brain diseases such as:

Brainstem lesions in traumatic brain injury

In the event of a traumatic brain injury the presence of a brainstem lesion has a significant impact in the prognosis of the patient. Although the development of MRI has allowed for very effective detection of brainstem lesions, evoked potentials measurements are also an electrophysiological technique that has been used for over 30 years in this context.[4]

Dementia

Dementia is a progressive, degenerative brain disease that impairs cognitive functions.[5] Alzheimer's disease and other types of dementia diagnosis is being improved through the use of electroencephalogram (EEG) and event-related potentials(ERP).

Epilepsy

Abnormally excessive or synchronous neuronal activity in the brain can cause seizures. These symptoms are characteristic of the neurological disorder known as epilepsy. Epilepsy is typically diagnosed with an EEG test.[6] However, the effectiveness of MEG in the diagnosis of neocortical epilepsy has also been established.[7]

Parkinson's disease

Parkinson's disease is a degenerative ailment that affects the central nervous system and is typically identified initially by its motor related symptoms. Accurate differentiation of PD from any other neurological disorder and the identification of the disease course is important in establishing an appropriate antiparkinsonian therapy. In the diagnostic role, surface EMG is a very informative method used to obtain relevant quantitative characteristics.[citation needed]

Magnetoencephalography (MEG)

The measurement of the naturally occurring magnetic fields produced by the brain's electrical activity is called magnetoencephalography. This method differs from magnetic resonance imaging in that it passively measures the magnetic fields without altering the body's magnetization. However, data from MEG and MRI can be combined to create images that approximately map the estimated location of the natural magnetic fields. This composite imaging process is called magnetic source imaging (MSI).

Electrocardiography (EKG)

The heart is the muscle that pumps oxygenated blood to the whole body. In order for the heart to contract in a regular, organized manner, specific electrical signals are sent to the myocardium from the pacemaker cells. These cardiac, electrical signals produce a peculiar pattern that can be measured and analyzed. Electrocardiography is the measurement of these signals. EKGs are cheap, non-invasive and provide immediate results which has allowed for their proliferation of use in medicine. EKGs can be ordered as a one-time test, or can be continuously monitored in the case of patients wearing a holter monitor and/or admitted to a telemetry unit. EKGs provide information about heart rate, heart rhythms and provide some data on underlying myocardium, valves and coronary vessels. EKGs can be used to aid in the diagnosis of myocardial infarction, arrhythmia, left ventricular hyptertrophy, valvulopathies, and coronary artery disease.

Electromyography (EMG)

Electromyography is the measurement and analysis of the electrical activity in skeletal muscles. This technique is useful for diagnosing the health of the muscle tissue and the nerves that control them.[8] EMG measures action potentials, called Motor Unit Action Potentials (MUAPs), created during muscle contraction. A few common uses are determining whether a muscle is active or inactive during movement (onset of activity), assessing the velocity of nerve conduction, and the amount of force generated during movement. EMGs are the basis for nerve conduction studies which measure the electrical conduction velocity and other characteristics of nerves in the body. EMGs can be used to diagnose and monitor neurological diseases such as:

Carpal tunnel syndrome (CTS)

The compression of the median nerve within the carpal canal of the wrist and the progression of symptoms resulting from this entrapment is known as carpal tunnel syndrome (CTS). Nerve conduction studies have been used as a control electrophysiological method in the development of better CTS diagnostic techniques.[9]

Essential tremor

It is hard to diagnose essential tremor and differentiate it from other types of tremor.[10] The burst discharge patterns of EMG signals is compared to the frequency and amplitude of videotaped tremors to evaluate and diagnose essential tremor.

Spasticity

Spasticity is a velocity dependent resistance to stretch. [11] The most commonly affected muscles are those that oppose gravity, the elbow and wrist flexors, knee extensors and ankle plantarflexors.[12] Spasticity is a side effect of multiple central nervous system disorders including Cerebral Palsy, Stroke, Multiple Sclerosis and spinal cord injuries and results in limited joint range of motion of the affected limb.[13] Electromyography (EMG) has been proposed by multiple researchers as an alternative measurement technique to quantify spasticity. The use of EMG offers a quantitative value of severity as opposed to relying on subjective scoring protocols.[14][15]

Multiple sclerosis

The demyelination and scarring of axons in the neurons of the nervous system can affect their conduction properties and seriously harm the normal communication of the brain with the rest of the body. Multiple sclerosis (MS) is a disease that causes this deterioration of the myelin sheath. There isn't a unique test to diagnose MS and several studies must be combined to determine the presence of this disease. However, visual evoked potentials do play a role in the whole diagnostic process.[16]

References

  1. ↑ L. Jasmin "EEG"
  2. ↑ Duffy, FH; Hughes, JR; Miranda, F; Bernad, P; Cook, P (October 1994). "Status of quantitative EEG (QEEG) in clinical practice, 1994.". Clinical Electroencephalography 25 (4): VI–XXII. doi:10.1177/155005949402500403. PMID 7813090. Archived from the original on 2015-02-17. https://web.archive.org/web/20150217132002/http://qeegsupport.com/wp-content/uploads/2009/04/MEGAhandout/Duffyetal1994.pdf. 
  3. ↑ Bressler, S. L. and Ding, M. 2006. "Event-Related Potentials". Wiley Encyclopedia of Biomedical Engineering.
  4. ↑ Wedekind, Christoph; Hesselmann, Volker; Klug, Norfrid (August 2002). "Comparison of MRI and electrophysiological studies for detecting brainstem lesions in traumatic brain injury". Muscle & Nerve 26 (2): 270–273. doi:10.1002/mus.10187. PMID 12210392. 
  5. ↑ Ifeachor, E. C., et al, "Biopattern Analysis and Subject-Specific Diagnosis and Care of Dementia "., Engineering in Medicine and Biology 27th Annual Conference, September 2005
  6. ↑ A.D.A.M. Medical Encyclopedia., "Epilepsy - PubMed Health". Retrieved 27 July 2012
  7. ↑ H. Stefan, "The Role of MEG in Epilepsy Diagnosis and Treatment", ACNR, Volume 4, No 2, May/June 2004
  8. ↑ Mayo Clinic Staff, "Electromyography (EMG)". Retrieved 27 July 2012
  9. ↑ Yagci, Ilker; Gunduz, Osman Hakan; Sancak, Seda; Agirman, Mehmet; Mesci, Erkan; Akyuz, Gulseren (May 2010). "Comparative electrophysiological techniques in the diagnosis of carpal tunnel syndrome in patients with diabetic polyneuropathy". Diabetes Research and Clinical Practice 88 (2): 157–163. doi:10.1016/j.diabres.2010.02.011. PMID 20223548. http://www.diabetesresearchclinicalpractice.com/article/S0168-8227(10)00087-2/abstract. 
  10. ↑ Louis, Elan D.; Pullman, Seth L. (July 2001). "Comparison of Clinical vs Electrophysiological Methods of Diagnosing of Essential Tremor". Movement Disorders 16 (4): 668–673. doi:10.1002/mds.1144. PMID 11481690. http://www.cmpl.columbia.edu/research/docs/compar_clinical_electrophysOfDxET14.pdf. Retrieved 2012-07-28. 
  11. ↑ Lance, J.W., The control of muscle tone, reflexes, and movement: Robert Wartenberg Lecture, Neurology, 30 (1980) 1303- 1313.
  12. ↑ Ansari, NN; Naghdi, S; Arab, TK; Jalaie, S (2008). "The interrater and intrarater reliability of the Modified Ashworth Scale in the assessment of muscle spasticity: limb and muscle group effect.". NeuroRehabilitation 23 (3): 231–7. doi:10.3233/NRE-2008-23304. PMID 18560139. 
  13. ↑ "Exede Satellite Internet | Exede Internet". Archived from the original on 2012-09-20. https://web.archive.org/web/20120920142814/http://www.wemove.org/spa/. Retrieved 2012-11-01. 
  14. ↑ Malhotra, S; Cousins, E; Ward, A; Day, C; Jones, P; Roffe, C; Pandyan, A (2008). "An investigation into the agreement between clinical, biomechanical, and neurophysiological measures of spasticity". Clinical Rehabilitation 22 (12): 1105–1115. doi:10.1177/0269215508095089. PMID 19052249. 
  15. ↑ Castilho, J.; Ferreira, L. A. B.; Pereira, W. M.; Neto, H. P.; Morelli, J. G. S.; Brandalize, D.; Kerppers, I. I.; Oliveria, C. S. (July 2012). "Analysis of electromyographic activity in spastic biceps brachii muscle following neural mobilization". Journal of Bodywork and Movement Therapies 16 (3): 364–368. doi:10.1016/j.jbmt.2011.12.003. PMID 22703748. 
  16. ↑ McDonald, W. I.; Compston, A.; Edan, G.; Goodkin, D.; Hartung, H.-P.; Lublin, F. D.; McFarland, H. F.; Paty, D. W. et al. (July 2001). "Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis". Annals of Neurology 50 (1): 121–127. doi:10.1002/ana.1032. PMID 11456302. http://www.msdiagnosed.org/McDonald.pdf. 



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