Biology:Exosome component 10

Generic protein structure example

Exosome component 10, also known as EXOSC10, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.

Further reading

• "Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD protein.". J. Exp. Med. 176 (4): 973–80. 1992. doi:10.1084/jem.176.4.973. PMID 1383382. 
• "Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen.". J. Clin. Invest. 90 (2): 559–70. 1992. doi:10.1172/JCI115895. PMID 1644924. 
• "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.". Genes Dev. 13 (16): 2148–58. 1999. doi:10.1101/gad.13.16.2148. PMID 10465791. 
• "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. 2001. doi:10.1074/jbc.M007603200. PMID 11110791. 
• "The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.". Genes Immun. 2 (3): 119–27. 2001. doi:10.1038/sj.gene.6363745. PMID 11426320. 
• "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. 2002. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. 
• "Protein-protein interactions of hCsl4p with other human exosome subunits.". J. Mol. Biol. 315 (4): 809–18. 2002. doi:10.1006/jmbi.2001.5265. PMID 11812149. 
• "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.". Arthritis Res. 4 (2): 134–8. 2002. doi:10.1186/ar389. PMID 11879549. 
• "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653–63. 2002. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256. 
• "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. 2003. doi:10.1091/mbc.E02-05-0271. PMID 12429849. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. 
• "The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus.". J. Biol. Chem. 278 (33): 30698–704. 2003. doi:10.1074/jbc.M302488200. PMID 12788944. 
• "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.". Mol. Cell 12 (3): 675–87. 2003. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. 2004. doi:10.1038/ncb1086. PMID 14743216. 
• "PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome.". Arthritis Rheum. 50 (2): 565–9. 2004. doi:10.1002/art.20056. PMID 14872500. 
• "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. 2004. doi:10.1101/gr.2122004. PMID 15231747. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.". RNA 13 (7): 1027–35. 2007. doi:10.1261/rna.575107. PMID 17545563.