Biology:Exosome component 2

Generic protein structure example

Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene.

Function

Mammalian mRNAs contain AU-rich elements (AREs) within their three prime untranslated regions. In yeast, 3-prime-to-5-prime mRNA degradation is mediated by the exosome, a multisubunit particle. EXOSC2 (which is homologous to the yeast Rrp4 protein) is a component of the human exosome.

Interactions

Exosome component 2 has been shown to interact with:

• Exosome component 4, and
• Exosome component 7.

Further reading

• "Sequence identification of 2,375 human brain genes.". Nature 355 (6361): 632–4. 1992. doi:10.1038/355632a0. PMID 1538749. Bibcode: 1992Natur.355..632A. 
• "Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia.". Blood 78 (4): 1078–84. 1991. doi:10.1182/blood.V78.4.1078.1078. PMID 1868241. 
• "Characterization of the human ABL promoter regions.". Oncogene 5 (6): 885–91. 1990. PMID 2163052. 
• "A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia.". Leukemia 4 (6): 397–403. 1990. PMID 2193202. 
• "Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation.". Nucleic Acids Res. 17 (19): 7631–42. 1989. doi:10.1093/nar/17.19.7631. PMID 2678002. 
• "Structural organization of the bcr gene and its role in the Ph' translocation.". Nature 315 (6022): 758–61. 1985. doi:10.1038/315758a0. PMID 2989703. Bibcode: 1985Natur.315..758H. 
• "Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.". Cell 47 (2): 277–84. 1986. doi:10.1016/0092-8674(86)90450-2. PMID 3021337. 
• "The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript.". Mol. Cell. Biol. 6 (2): 607–16. 1987. doi:10.1128/mcb.6.2.607. PMID 3023859. 
• "The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia.". Mol. Cell. Biol. 7 (9): 3231–6. 1987. doi:10.1128/mcb.7.9.3231. PMID 3313010. 
• "Isolation of human oncogene sequences (v-fes homolog) from a cosmid library.". Science 216 (4550): 1136–8. 1982. doi:10.1126/science.6281890. PMID 6281890. Bibcode: 1982Sci...216.1136G. 
• "The human v-abl cellular homologue.". J. Mol. Appl. Genet. 2 (1): 57–68. 1983. PMID 6302194. 
• "Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia.". Nature 306 (5940): 239–42. 1984. doi:10.1038/306239a0. PMID 6316147. 
• "Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22.". Cell 36 (1): 93–9. 1984. doi:10.1016/0092-8674(84)90077-1. PMID 6319012. 
• "Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.". Genomics 27 (1): 67–82. 1995. doi:10.1006/geno.1995.1008. PMID 7665185. 
• "Duplication of small segments within the major breakpoint cluster region in chronic myelogenous leukemia.". Blood 81 (6): 1567–72. 1993. doi:10.1182/blood.V81.6.1567.1567. PMID 8453102. 
• "The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.". Genes Dev. 10 (4): 502–13. 1996. doi:10.1101/gad.10.4.502. PMID 8600032. 
• "The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases.". Cell 91 (4): 457–66. 1997. doi:10.1016/S0092-8674(00)80432-8. PMID 9390555. 
• "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.". Genes Dev. 13 (16): 2148–58. 1999. doi:10.1101/gad.13.16.2148. PMID 10465791. 
• "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. 2001. doi:10.1074/jbc.M007603200. PMID 11110791. 
• "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. 2002. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.