Biology:FGF18
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene.[1][2][3]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. FGF18 signals through fibroblast growth factor receptor FGFR3 to promote chondrogenesis[4] and has been shown to cause thickening of cartilage in a murine model of osteoarthritis,[5] and the recombinant version of it (sprifermin) is in clinical trial as a potential treatment for osteoarthritis.[6] Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.[3]
References
- ↑ "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18". J Biol Chem 273 (29): 18161–4. Aug 1998. doi:10.1074/jbc.273.29.18161. PMID 9660775.
- ↑ "FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation". Mol Cell Biol 18 (10): 6063–74. Nov 1998. doi:10.1128/MCB.18.10.6063. PMID 9742123.
- ↑ 3.0 3.1 "Entrez Gene: FGF18 fibroblast growth factor 18". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8817.
- ↑ Davidson, D.; Blanc, A.; Filion, D.; Wang, H.; Plut, P.; Pfeffer, G.; Buschmann, M. D.; Henderson, J. E. (2005). "Fibroblast Growth Factor (FGF) 18 Signals through FGF Receptor 3 to Promote Chondrogenesis". Journal of Biological Chemistry 280 (21): 20509–20515. doi:10.1074/jbc.M410148200. PMID 15781473.
- ↑ Moore, E.; Bendele, A.; Thompson, D.; Littau, A.; Waggie, K.; Reardon, B.; Ellsworth, J. (2005). "Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis". Osteoarthritis and Cartilage 13 (7): 623–631. doi:10.1016/j.joca.2005.03.003. PMID 15896984.
- ↑ Merck Announces Collaboration With Nordic Bioscience for Sprifermin in Osteoarthritis of the Knee, http://www.merckgroup.com/en/media/extNewsDetail.html?newsId=502569FC1F1AFE50C1257B2F00538E80&newsType=1, retrieved 2013-04-02
Further reading
- "A review of FGF18: Its expression, signaling pathways and possible functions during embryogenesis and post-natal development". Histol. Histopathol. 22 (1): 97–105. 2007. PMID 17128416.
- "Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is mapped to chromosome 14p11". Oncogene 18 (16): 2635–42. 1999. doi:10.1038/sj.onc.1202616. PMID 10353607.
- "Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures". Development 127 (9): 1833–43. 2000. doi:10.1242/dev.127.9.1833. PMID 10751172.
- "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- Whitmore TE; Maurer MF; Sexson S et al. (2001). "Assignment of fibroblast growth factor 18 (FGF18) to human chromosome 5q34 by use of radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet. Cell Genet. 90 (3–4): 231–3. doi:10.1159/000056775. PMID 11124520.
- Simpson JC; Wellenreuther R; Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Clark HF; Gurney AL; Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
- "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J. Biol. Chem. 279 (38): 40146–52. 2004. doi:10.1074/jbc.M405795200. PMID 15199049.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Wiemann S; Arlt D; Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
- "Expression of fibroblast growth factors 18 and 23 during human embryonic and fetal development". Gene Expr. Patterns 5 (4): 569–73. 2005. doi:10.1016/j.modgep.2004.10.008. PMID 15749088.
- Antoine M; Wirz W; Tag CG et al. (2005). "Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells". Growth Factors 23 (2): 87–95. doi:10.1080/08977190500096004. PMID 16019430.
- Mehrle A; Rosenfelder H; Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
- Antoine M; Wirz W; Tag CG et al. (2006). "Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation". Biochem. Biophys. Res. Commun. 346 (1): 224–33. doi:10.1016/j.bbrc.2006.05.105. PMID 16756958.
- Riley BM; Mansilla MA; Ma J et al. (2007). "Impaired FGF signaling contributes to cleft lip and palate". Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4512–7. doi:10.1073/pnas.0607956104. PMID 17360555. Bibcode: 2007PNAS..104.4512R.
External links
- Overview of all the structural information available in the PDB for UniProt: O76093 (Fibroblast growth factor 18) at the PDBe-KB.
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