Biology:FHL5

Generic protein structure example

Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene.

Function

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene.

Interactions

FHL5 has been shown to interact with CREB1 and CAMP responsive element modulator.

Further reading

• "Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT". Mol. Cell. Endocrinol. 179 (1–2): 17–23. 2001. doi:10.1016/S0303-7207(01)00463-4. PMID 11420126. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature 398 (6723): 165–9. 1999. doi:10.1038/18237. PMID 10086359. Bibcode: 1999Natur.398..165F. 
• "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. 2000. doi:10.1128/MCB.20.22.8613-8622.2000. PMID 11046156. 
• "Cloning and expression of activator of CREM in testis in human testicular tissue". Biochem. Biophys. Res. Commun. 283 (2): 406–11. 2001. doi:10.1006/bbrc.2001.4805. PMID 11327716. 
• "Expression of cAMP-responsive element binding protein and inducible cAMP early repressor in hyperfunctioning thyroid adenomas". Eur. J. Endocrinol. 146 (6): 759–66. 2002. doi:10.1530/eje.0.1460759. PMID 12039695. 
• "CREM-dependent transcription in male germ cells controlled by a kinesin". Science 298 (5602): 2388–90. 2002. doi:10.1126/science.1077265. PMID 12493914. Bibcode: 2002Sci...298.2388M. 
• "The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF". Mol. Cell 16 (6): 867–80. 2004. doi:10.1016/j.molcel.2004.11.039. PMID 15610731. 
• "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males". Mol. Hum. Reprod. 12 (4): 257–62. 2006. doi:10.1093/molehr/gal006. PMID 16687568. 
• "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 

External links

• FHL5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.