Biology:CREB1
From HandWiki
Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene.[1][2] This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.
This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[3]
See also
Interactions
CREB1 has been shown to interact with:
- CEBPB,[4]
- CREB binding protein,[5][6][7][8][9][10][11][12][13][14]
- FHL2,[15]
- FHL3,[15]
- FHL5.[15]
- HTATIP,[16]
- P53,[11] and
- RPS6KA5.[17][18]
References
- ↑ "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA". Science 242 (4884): 1430–3. Dec 1988. doi:10.1126/science.2974179. PMID 2974179. Bibcode: 1988Sci...242.1430H.
- ↑ "Assignment of the human gene for CREB1 to chromosome 2q32.3-q34". Genomics 7 (3): 416–21. Jul 1990. doi:10.1016/0888-7543(90)90176-U. PMID 2142119.
- ↑ "Entrez Gene: CREB1 cAMP responsive element binding protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1385.
- ↑ "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta". Molecular and Cellular Biology 23 (12): 4066–82. Jun 2003. doi:10.1128/MCB.23.12.4066-4082.2003. PMID 12773552.
- ↑ "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress". Proceedings of the National Academy of Sciences of the United States of America 101 (16): 5898–903. Apr 2004. doi:10.1073/pnas.0307718101. PMID 15073328. Bibcode: 2004PNAS..101.5898S.
- ↑ "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus". Journal of Molecular Endocrinology 34 (1): 107–18. Feb 2005. doi:10.1677/jme.1.01701. PMID 15691881.
- ↑ "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein". The Journal of Biological Chemistry 271 (30): 17957–60. Jul 1996. doi:10.1074/jbc.271.30.17957. PMID 8663317.
- ↑ "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions". Cell 91 (6): 741–52. Dec 1997. doi:10.1016/S0092-8674(00)80463-8. PMID 9413984.
- ↑ "CBP alleviates the intramolecular inhibition of ATF-2 function". The Journal of Biological Chemistry 273 (44): 29098–105. Oct 1998. doi:10.1074/jbc.273.44.29098. PMID 9786917.
- ↑ "Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators". The Journal of Biological Chemistry 277 (44): 42241–8. Nov 2002. doi:10.1074/jbc.M207361200. PMID 12196545.
- ↑ 11.0 11.1 "p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation". Molecular and Cellular Biology 20 (13): 4849–58. Jul 2000. doi:10.1128/MCB.20.13.4849-4858.2000. PMID 10848610.
- ↑ "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB". Molecular and Cellular Biology 20 (14): 4970–8. Jul 2000. doi:10.1128/MCB.20.14.4970-4978.2000. PMID 10866654.
- ↑ "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology 21 (7): 2249–58. Apr 2001. doi:10.1128/MCB.21.7.2249-2258.2001. PMID 11259575.
- ↑ "Ca2+-dependent block of CREB-CBP transcription by repressor DREAM". The EMBO Journal 21 (17): 4583–92. Sep 2002. doi:10.1093/emboj/cdf440. PMID 12198160.
- ↑ 15.0 15.1 15.2 "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Molecular and Cellular Biology 20 (22): 8613–22. Nov 2000. doi:10.1128/MCB.20.22.8613-8622.2000. PMID 11046156.
- ↑ "Tip60 inhibits activation of CREB protein by protein kinase A". Biochemical and Biophysical Research Communications 269 (3): 758–66. Mar 2000. doi:10.1006/bbrc.2000.2358. PMID 10720489.
- ↑ "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal 17 (15): 4426–41. Aug 1998. doi:10.1093/emboj/17.15.4426. PMID 9687510.
- ↑ "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase". The EMBO Journal 20 (16): 4370–9. Aug 2001. doi:10.1093/emboj/20.16.4370. PMID 11500364.
Further reading
- "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". Molecular and Cellular Endocrinology 187 (1–2): 115–24. Feb 2002. doi:10.1016/S0303-7207(01)00696-7. PMID 11988318.
- "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction". Pharmacology & Therapeutics 104 (1): 47–58. Oct 2004. doi:10.1016/j.pharmthera.2004.08.002. PMID 15500908.
- "Transducer of regulated CREB and late phase long-term synaptic potentiation". The FEBS Journal 274 (13): 3218–23. Jul 2007. doi:10.1111/j.1742-4658.2007.05891.x. PMID 17565597.
- "CREB and cAMP response element-mediated gene expression in the ischemic brain". The FEBS Journal 274 (13): 3210–7. Jul 2007. doi:10.1111/j.1742-4658.2007.05890.x. PMID 17565598.
- "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". The FEBS Journal 274 (13): 3202–9. Jul 2007. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599.
- "CREB--a real culprit in oncogenesis". The FEBS Journal 274 (13): 3224–32. Jul 2007. doi:10.1111/j.1742-4658.2007.05884.x. PMID 17565603.
External links
- CREB1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CREB1 genome location and CREB1 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
PDB gallery | |
|---|---|
|
 |  |
