Biology:Frataxin-like domain
From HandWiki
| Frataxin-like domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 mature human frataxin | |||||||||
| Identifiers | |||||||||
| Symbol | Frataxin_Cyay | ||||||||
| Pfam | PF01491 | ||||||||
| InterPro | IPR002908 | ||||||||
| SCOP2 | 1dlx / SCOPe / SUPFAM | ||||||||
| TCDB | 9.B.21 | ||||||||
| CDD | cd00503 | ||||||||
| |||||||||
In molecular biology, the frataxin-like domain is a protein domain found in proteins including eukaryotic frataxin and bacterial CyaY.
The bacterial CyaY proteins are iron-sulphur cluster (FeS) metabolism proteins which are homologous to eukaryotic frataxin. Partial phylogenetic profiling suggests that CyaY most likely functions as part of the ISC system for FeS cluster biosynthesis, and is supported by experimental data in some species.[1][2][3]
References
- ↑ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic". BMC Biol. 4: 29. 2006. doi:10.1186/1741-7007-4-29. PMID 16930487.
- ↑ "Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU". J. Biol. Chem. 281 (24): 16256–63. June 2006. doi:10.1074/jbc.M513569200. PMID 16603772.
- ↑ "Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo". J. Bacteriol. 188 (3): 1175–9. February 2006. doi:10.1128/JB.188.3.1175-1179.2006. PMID 16428423.
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