Biology:GCNT1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the GCNT1 gene.[1][2][3]
This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified.[3]
References
- ↑ "Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family". Genes Dev 7 (3): 468–78. Apr 1993. doi:10.1101/gad.7.3.468. PMID 8449405.
- ↑ "Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches". J Biol Chem 274 (5): 3215–21. Mar 1999. doi:10.1074/jbc.274.5.3215. PMID 9915862.
- ↑ 3.0 3.1 "Entrez Gene: GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2650.
Further reading
- "Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.". Proc. Natl. Acad. Sci. U.S.A. 89 (19): 9326–330. 1992. doi:10.1073/pnas.89.19.9326. PMID 1329093. Bibcode: 1992PNAS...89.9326B.
- "Genomic organization of core 2 and I branching beta-1,6-N-acetylglucosaminyltransferases. Implication for evolution of the beta-1,6-N-acetylglucosaminyltransferase gene family.". Glycobiology 5 (4): 417–25. 1995. doi:10.1093/glycob/5.4.417. PMID 7579796.
- "Altered Golgi localization of core 2 beta-1,6-N-acetylglucosaminyltransferase leads to decreased synthesis of branched O-glycans.". J. Biol. Chem. 272 (36): 22695–702. 1997. doi:10.1074/jbc.272.36.22695. PMID 9278427.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Mucin biosynthesis: epidermal growth factor downregulates core 2 enzymes in a human airway adenocarcinoma cell line.". Am. J. Respir. Cell Mol. Biol. 29 (1): 48–56. 2003. doi:10.1165/rcmb.2002-0147OC. PMID 12600830.
- "Multiple transcription initiation and alternative splicing in the 5' untranslated region of the core 2 beta1-6 N-acetylglucosaminyltransferase I gene.". Glycobiology 13 (6): 411–8. 2004. doi:10.1093/glycob/cwg039. PMID 12626388.
- "Protein kinase C beta2-dependent phosphorylation of core 2 GlcNAc-T promotes leukocyte-endothelial cell adhesion: a mechanism underlying capillary occlusion in diabetic retinopathy.". Diabetes 52 (6): 1519–27. 2003. doi:10.2337/diabetes.52.6.1519. PMID 12765965.
- "Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 in rolling on P-selectin.". J. Biol. Chem. 279 (21): 21984–91. 2004. doi:10.1074/jbc.M402731200. PMID 15026421.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "Not core 2 beta 1,6-N-acetylglucosaminyltransferase-2 or -3 but -1 regulates sialyl-Lewis x expression in human precursor B cells.". Glycobiology 15 (3): 271–80. 2005. doi:10.1093/glycob/cwi005. PMID 15483269.
- "Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line.". Am. J. Physiol. Lung Cell Mol. Physiol. 288 (1): L116–24. 2005. doi:10.1152/ajplung.00370.2003. PMID 15591039.
- "An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer.". Biochem. Biophys. Res. Commun. 331 (4): 958–63. 2005. doi:10.1016/j.bbrc.2005.04.022. PMID 15882971.
- "N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding.". Biochem. J. 391 (Pt 3): 491–502. 2006. doi:10.1042/BJ20050344. PMID 15926890.
- "Expression of core 2 beta1,6-N-acetylglucosaminyltransferase facilitates prostate cancer progression.". Glycobiology 15 (10): 1016–24. 2006. doi:10.1093/glycob/cwi086. PMID 15932919.
- "Transfection of antisense core 2 beta1,6-N-acetylglucosaminyltransferase-1 cDNA suppresses selectin ligand expression and tissue infiltration of B-cell precursor leukemia cells.". Leukemia 19 (11): 1934–40. 2005. doi:10.1038/sj.leu.2403951. PMID 16179912.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death.". Blood 108 (7): 2399–406. 2006. doi:10.1182/blood-2006-04-018556. PMID 16778138.
- "Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I.". J. Immunol. 179 (9): 5701–10. 2007. doi:10.4049/jimmunol.179.9.5701. PMID 17947642.
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