Biology:GGA1
 Generic protein structure example |
ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.[1][2][3]
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[4]
Interactions
GGA1 has been shown to interact with Sortilin 1,[5] BACE2,[6] RABEP1[7] and ARF3.[8][9]
References
- ↑ "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J Cell Biol 149 (1): 67–80. May 2000. doi:10.1083/jcb.149.1.67. PMID 10747088.
- ↑ "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J Cell Biol 149 (1): 81–94. May 2000. doi:10.1083/jcb.149.1.81. PMID 10747089.
- ↑ "Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles". J Biol Chem 281 (11): 7253–9. March 2006. doi:10.1074/jbc.M511313200. PMID 16407204.
- ↑ "Entrez Gene: GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26088.
- ↑ Jacobsen, Linda; Madsen Peder; Nielsen Morten S; Geraerts Wijnand P M; Gliemann Jørgen; Smit August B; Petersen Claus M (January 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. ISSN 0014-5793. PMID 11821067.
- ↑ He, Xiangyuan; Chang Wan-Pin; Koelsch Gerald; Tang Jordan (July 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. ISSN 0014-5793. PMID 12135764.
- ↑ Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. ISSN 0261-4189. PMID 12505986.
- ↑ Boman, Annette L; Salo Paul D; Hauglund Melissa J; Strand Nicole L; Rensink Shelly J; Zhdankina Olga (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. ISSN 1059-1524. PMID 12221117.
- ↑ Boman, A L; Zhang C j; Zhu X; Kahn R A (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol. Biol. Cell 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. ISSN 1059-1524. PMID 10749927.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi.". Mol. Biol. Cell 11 (4): 1241–55. 2000. doi:10.1091/mbc.11.4.1241. PMID 10749927.
- "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin.". Biochem. Biophys. Res. Commun. 271 (3): 719–25. 2000. doi:10.1006/bbrc.2000.2700. PMID 10814529.
- "Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi.". Yeast 18 (1): 1–18. 2001. doi:10.1002/1097-0061(200101)18:1<1::AID-YEA644>3.0.CO;2-5. PMID 11124697.
- "The GGAs promote ARF-dependent recruitment of clathrin to the TGN.". Cell 105 (1): 93–102. 2001. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005.
- "Sorting of mannose 6-phosphate receptors mediated by the GGAs.". Science 292 (5522): 1712–6. 2001. doi:10.1126/science.1060750. PMID 11387475. Bibcode: 2001Sci...292.1712P.
- "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains.". J. Biol. Chem. 276 (30): 28541–5. 2001. doi:10.1074/jbc.C100218200. PMID 11390366.
- "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.". FEBS Lett. 511 (1–3): 155–8. 2002. doi:10.1016/S0014-5793(01)03299-9. PMID 11821067.
- "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.". Nature 415 (6874): 937–41. 2002. doi:10.1038/415937a. PMID 11859376. Bibcode: 2002Natur.415..937S.
- "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.". Biochem. J. 365 (Pt 2): 369–78. 2002. doi:10.1042/BJ20020428. PMID 11950392.
- "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8072–7. 2002. doi:10.1073/pnas.082235699. PMID 12060753. Bibcode: 2002PNAS...99.8072D.
- "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.". FEBS Lett. 524 (1–3): 183–7. 2002. doi:10.1016/S0014-5793(02)03052-1. PMID 12135764.
- "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization.". Mol. Biol. Cell 13 (9): 3078–95. 2003. doi:10.1091/mbc.E02-02-0078. PMID 12221117.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex.". EMBO J. 22 (1): 78–88. 2003. doi:10.1093/emboj/cdg015. PMID 12505986.
- "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking.". J. Cell Biol. 160 (2): 213–22. 2003. doi:10.1083/jcb.200208023. PMID 12538641.
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