Biology:GPVI

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Glycoprotein VI (platelet), also known as GPVI, is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GPVI gene. GPVI was first cloned in 2000 by several groups including that of Martine Jandrot-Perrus from INSERM.

Function

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.

Complete or partial deficiency of GPVI in humans is a rare condition presenting as a mild bleeding disorder.

Interactions

GPVI has been shown to interact with LYN.

See also

• collagen receptor

Further reading

• "Platelet-collagen interaction: is GPVI the central receptor?". Blood 102 (2): 449–61. Jul 2003. doi:10.1182/blood-2002-12-3882. PMID 12649139. 
• "GPVI and integrin alphaIIb beta3 signaling in platelets". Journal of Thrombosis and Haemostasis 3 (8): 1752–62. Aug 2005. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042. 
• "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets". Proceedings of the National Academy of Sciences of the United States of America 88 (17): 7844–8. Sep 1991. doi:10.1073/pnas.88.17.7844. PMID 1715582. Bibcode: 1991PNAS...88.7844H. 
• "A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion". The Journal of Clinical Investigation 84 (5): 1440–5. Nov 1989. doi:10.1172/JCI114318. PMID 2808700. 
• "Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor". The Journal of Biological Chemistry 272 (21): 13576–83. May 1997. doi:10.1074/jbc.272.21.13576. PMID 9153205. 
• "Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain". FEBS Letters 413 (2): 255–9. Aug 1997. doi:10.1016/S0014-5793(97)00926-5. PMID 9280292. 
• "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets". The Journal of Biological Chemistry 272 (38): 23528–31. Sep 1997. doi:10.1074/jbc.272.38.23528. PMID 9295288. 
• "The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors". The Journal of Biological Chemistry 274 (41): 29019–24. Oct 1999. doi:10.1074/jbc.274.41.29019. PMID 10506151. 
• "Cloning and expression of the platelet-specific collagen receptor glycoprotein VI". Thrombosis Research 98 (4): 301–9. May 2000. doi:10.1016/S0049-3848(00)00182-1. PMID 10822077. 
• "Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain". The Journal of Biological Chemistry 275 (31): 23998–4002. Aug 2000. doi:10.1074/jbc.M003803200. PMID 10825177. 
• "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily". Blood 96 (5): 1798–807. Sep 2000. doi:10.1182/blood.V96.5.1798. PMID 10961879. 
• "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI". Biochemical and Biophysical Research Communications 277 (1): 27–36. Oct 2000. doi:10.1006/bbrc.2000.3624. PMID 11027634. 
• "Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI". The Journal of Biological Chemistry 277 (15): 12874–8. Apr 2002. doi:10.1074/jbc.M200482200. PMID 11825911. 
• "Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling". The Journal of Biological Chemistry 277 (24): 21561–6. Jun 2002. doi:10.1074/jbc.M201012200. PMID 11943772. 
• "Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP". Blood 99 (9): 3228–34. May 2002. doi:10.1182/blood.V99.9.3228. PMID 11964287. 
• "Differences in adhesion receptor expression between immature and older platelets and red blood cells of neonates and adults". Journal of Pediatric Hematology/Oncology 24 (2): 120–4. Feb 2002. doi:10.1097/00043426-200202000-00012. PMID 11990697. 
• "Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI". Blood 99 (11): 4219–21. Jun 2002. doi:10.1182/blood-2001-11-0008. PMID 12010829. http://www.bloodjournal.org/content/bloodjournal/99/11/4219.full.pdf. 
• "Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets". The Biochemical Journal 364 (Pt 3): 755–65. Jun 2002. doi:10.1042/BJ20020128. PMID 12049640. 
• "Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen". The Journal of Biological Chemistry 277 (48): 46197–204. Nov 2002. doi:10.1074/jbc.M204029200. PMID 12356768. 
• "Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1". The Journal of Biological Chemistry 277 (50): 48333–41. Dec 2002. doi:10.1074/jbc.M206127200. PMID 12359731. 

External links

• GPVI+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)