Biology:Gaseous mediator
From HandWiki
Gaseous mediators are chemicals that are produced in small amounts by some cells of the mammalian body and have a number of biological signalling functions. There are three so-far-identified gaseous mediator molecules: nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO).[1]
Clinical Applications
Endogenous gaseous mediators have shown anti-inflammatory and cytoprotective properties[2] Combination nonsteroidal anti-inflammatory drugs featuring both a cyclooxygenase inhibitor and gaseous mediator releasing component are being investigated as a safer alternative to current anti-inflammatory drugs[3] due to their potential reduction in risk for gastrointestinal ulcer formation.[4]
References
- ↑ Leffler, C. W.; Parfenova, H; Jaggar, J. H.; Wang, R (March 2006). "Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation". J. Appl. Physiol. 100 (3): 1065–76. doi:10.1152/japplphysiol.00793.2005. PMID 16467393.
- ↑ Rodrigues, L.; Ekundi-Valentim, E.; Florenzano, J.; Cerqueira, A. R. A.; Soares, A. G.; Schmidt, T. P.; Santos, K. T.; Teixeira, S. A. et al. (2017-01-01). "Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice" (in en). Pharmacological Research 115: 255–266. doi:10.1016/j.phrs.2016.11.006. ISSN 1043-6618. PMID 27840098. http://www.sciencedirect.com/science/article/pii/S1043661816305291.
- ↑ Sulaieva, Oksana; Wallace, John L (2015-12-01). "Gaseous mediator-based anti-inflammatory drugs" (in en). Current Opinion in Pharmacology. Gastrointestinal • Endocrine and metabolic diseases 25: 1–6. doi:10.1016/j.coph.2015.08.005. ISSN 1471-4892. http://www.sciencedirect.com/science/article/pii/S1471489215000983.
- ↑ Sulaieva, O. N.; Wallace, J. L. (2016). "New strategy for gastrointestinal protection based on gaseous mediators application". https://www.gastro-j.ru/jour/article/view/56.
 |  |
