Biology:Gem-associated protein 7

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.[1][2] The gem-associated proteins are those found in the gems of Cajal bodies.

Function

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[2]

Interactions

Gem-associated protein 7 has been shown to interact with SMN1[1][3] and Gem-associated protein 6.[1] [4]

References

  1. ↑ 1.0 1.1 1.2 "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry 277 (35): 31957–31962. Aug 2002. doi:10.1074/jbc.M203478200. PMID 12065586. 
  2. ↑ 2.0 2.1 "Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79760. 
  3. ↑ "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry 277 (9): 7540–7545. Mar 2002. doi:10.1074/jbc.M110141200. PMID 11748230. 
  4. ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 

Further reading

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Gem-associated protein 7




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