Biology:Ghretropin
From HandWiki
A ghretropin is a substance, usually a peptide, that increases the secretion of the "hunger hormone" ghrelin when consumed. Ghretropins that work on mice have been reported in the enzymatic digests of wheat, rice, and soy bean proteins. When a mouse consumes a purified version of the peptide, its plasma concentration of ghrelin and food intake increase.[1][2][3] If they also work on humans, they may represent a way to boost the appetite of elderly and anorexic people.[4]
List of ghretropins
| Name | Sequence | Year discovered | Effective in |
|---|---|---|---|
| Soy-ghretropin | NKNPFLFGSNR | 2016 | Mice (MGN3-1 cell culture, oral)[3] |
| Wheat ghretropin A | SQQQQPVLPQQPSF | 2021 | Mice (MGN3-1 cell culture, oral)[1] |
| Wheat ghretropin B | LSVTSPQQVSY | 2021 | Mice (MGN3-1 cell culture)[1] |
| Wheat ghretropin C | YPTSL | 2021 | Mice (MGN3-1 cell culture)[1] |
| Rice ghretropin A | QAFEPIRSV | 2022 | Mice (MGN3-1 cell culture, oral)[2] |
| Rice ghretropin B | TNPWHSPRQGSF | 2022 | Mice (MGN3-1 cell culture, oral)[2] |
References
- ↑ 1.0 1.1 1.2 1.3 Tanikawa, K; Kaneko, K; Abe, S; Nakato, J; Tokuyama, Y; Odaka, S; Iwakura, H; Sato, M et al. (April 2021). "Wheat-ghretropins: novel ghrelin-releasing peptides derived from wheat protein.". FEBS Open Bio 11 (4): 1144–1152. doi:10.1002/2211-5463.13124. PMID 33605550.
- ↑ 2.0 2.1 2.2 Kaneko, Kentaro; Tokuyama, Yuki; Taniguchi, Eriko; Abe, Shimon; Nakato, Junya; Iwakura, Hiroshi; Sato, Masaru; Kurabayashi, Atsushi et al. (11 January 2023). "Rice Endoplasmic Protein-Derived Peptides, Rice-Ghretropins A and B, Stimulate Ghrelin Release in MGN3-1 Cells and Increase Plasma Acylated Ghrelin and Food Intake in Mice". Journal of Agricultural and Food Chemistry 71 (1): 421–429. doi:10.1021/acs.jafc.2c05965. PMID 36580688. Bibcode: 2023JAFC...71..421K.
- ↑ 3.0 3.1 Nakato, J; Aoki, H; Iwakura, H; Suzuki, H; Kanamoto, R; Ohinata, K (August 2016). "Soy-ghretropin, a novel ghrelin-releasing peptide derived from soy protein.". FEBS Letters 590 (16): 2681–9. doi:10.1002/1873-3468.12306. PMID 27416956.
- ↑ "Soy-based protein could boost hunger for elderly & anorexic patients: Study" (in en). 26 July 2016. https://www.foodnavigator.com/Article/2016/07/27/Soy-based-protein-could-boost-hunger-for-elderly-anorexic-patients-Study/.
 |  |
