Biology:Glucose-6-phosphate exchanger SLC37A1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene.[1] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.[2]

Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis,[3] but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced.[4]

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Further reading