Biology:Glyphosate-based herbicides

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Short description: RoundUp and similar herbicides


Glyphosate-based herbicides are usually made of a glyphosate salt that is combined with other ingredients that are needed to stabilize the herbicide formula and allow penetration into plants. The glyphosate-based herbicide Roundup was first developed by Monsanto in the 1970s. It is used most heavily on corn, soy, and cotton crops that have been genetically modified to be resistant to the herbicide. Some products include two active ingredients, such as Enlist Duo which includes 2,4-D as well as glyphosate. As of 2010, more than 750 glyphosate products were on the market. The names of inert ingredients used in glyphosate formulations are usually not listed on the product labels.

Glyphosate and glyphosate-based herbicides have low acute toxicity in mammals. They likewise have not been shown to pose a significant risk to human health during normal use, although human deaths have been reported from deliberate ingestion of concentrated RoundUp. It is difficult to determine how much surfactants contribute to the overall toxicity of each formulation. Glyphosate formulations containing the surfactant polyethoxylated tallow amine (POEA) are sometimes used terrestrially, but are not approved for aquatic use in the US due to their toxicity to aquatic organisms.

There have been multiple lawsuits against Monsanto asserting that exposure to glyphosate herbicides is carcinogenic and that the company did not adequately disclose the risk to consumers. In 2018 a California jury awarded $289 million in damages (later cut to $78 million on appeal[1] then reduced to $21 million after another appeal[2]) to a groundskeeper who argued that Monsanto failed to adequately warn consumers of cancer risks posed by the herbicides.[3]

Background

The glyphosate-based herbicide RoundUp (styled: Roundup) was developed in the 1970s by Monsanto. Glyphosate was first registered for use in the U.S. in 1974.[4] Glyphosate-based herbicides were initially used in a similar way to paraquat and diquat, as non-selective herbicides. Attempts were made to apply them to row crops, but problems with crop damage kept glyphosate-based herbicides from being widely used for this purpose. In the US, use of glyphosate experienced rapid growth following the commercial introduction of a glyphosate-resistant soybean in 1996.[5] Between 1990 and 1996 sales of RoundUp increased around 20% per year.[6] (As of 2015) it is used in over 160 countries.[7] RoundUp is used most heavily on corn, soy, and cotton crops that have been genetically modified to withstand the chemical, but since 2012 glyphosate was used in California to treat other crops like almond, peach, cantaloupe, onion, cherry, sweet corn, and citrus.[7]

Bayer, which acquired Monsanto in 2018,[8] is the largest producer of glyphosate-based herbicides, but formulations from other manufacturers are available that use different inert ingredients. Other glyphosate-based formulations include Bronco, Glifonox, KleenUp, Ranger Pro (styled: Ranger PRO), Rodeo, and Weedoff.[9][10] Other manufacturers include Anhui Huaxing Chemical Industry Company, BASF, Dow AgroSciences, DuPont, Jiangsu Good Harvest-Weien Agrochemical Company, Nantong Jiangshan Agrochemical & Chemicals Co., Nufarm, SinoHarvest, Syngenta, and Zhejiang Xinan Chemical Industrial Group Company.[11] As of 2010, more than 750 glyphosate products were on the market.[4]

Inert ingredients

Surfactants, solvents, and preservatives are inert ingredients, or adjuvants, that are commonly added to glyphosate-based herbicide formulations.[12] Some products contain all the necessary adjuvants, including surfactant; some contain no adjuvant system, while other products contain only a limited amount of adjuvant. Some formulations require the addition of surfactants to the spray tank before application.[13][14][15] The names of inert ingredients used in glyphosate formulations are usually not listed on the product labels.[16]

Polyethoxylated tallow amine (POEA) is a surfactant added to Roundup and other herbicides as a wetting agent.[17] POEA is not a single surfactant, but a complex mixture. The composition of each POEA surfactant is a proprietary trade secret. Monsanto's RoundUp, for example, contains a proprietary POEA surfactant called MON 0818 at a 15% concentration.[18]

Regulatory history

European Union

As part of the process to renew glyphosate's license under EU regulations, a 2013 systematic review by the German Federal Institute for Risk Assessment (Bfr) of epidemiological studies of workers exposed to glyphosate formulations found no significant risk,[vague] stating that "the available data are contradictory and far from being convincing".[19] In 2015, as part of the ongoing renewal process, the European Food Safety Authority (EFSA) published a final risk assessment on 12 November 2015 stating that glyphosate met EU-level regulatory standards. Despite classifying glyphosate as non-carcinogenic, this report also acknowledged that some of the co-formulants added to glyphosate based pesticides "appeared to have toxic effects higher than the glyphosate itself", noting POEA in particular. The conclusion of the final EFSA assessment was that the active ingredient glyphosate met EU-level regulatory standards, but individual formulations would have to be evaluated by member states.[20]

There was insufficient support among the Member States for a 2016 European Commission proposal to renew the approval of glyphosate. Because the 2015 EFSA and IARC assessments had reached contradictory conclusions regarding the potential carcinogenicity of glyphosate, the European Chemicals Agency (ECHA) was asked to assess the hazard properties of the substance. Though no majority of Member States voted either for or against the renewal proposal, in July 2016 they voted to amend the conditions of glyphosate's existing approval. The new conditions require Member States to minimize the pre-harvest use of glyphosate products, as well as use in certain public places. Formulations that include the surfactant POEA were banned. These conditions were later included in the implementing act for the 5-year renewal that was approved on 12 December 2017.[21]

United States

In 2014 the EPA approved Enlist Duo, which was developed by Dow AgroSciences. This herbicide combined two active ingredients: 2,4-D and glyphosate. Enlist Duo is intended for use with genetically modified crops that have also been developed by the Dow Chemical subsidiary. The initial approval was limited to the states of Illinois, Indiana , Iowa, Ohio, South Dakota, and Wisconsin.[22] During the course of litigation in 2015, the EPA found out that Dow had told the United States Patent and Trademark Office that Enlist Duo offers "synergistic herbicidal weed control", and requested additional clarification about the "synergistic effects" and sought to reverse its approval pending a full review of the new information provided by Dow.[23][24] In 2016, the 9th Circuit rejected the EPA's petition to vacate its approval of the herbicide.[24]

Since some glyphosate herbicide formulations contain an inert ingredient that may be toxic to fish and amphibians, only formulations labeled for aquatic use are recommended when water contamination is possible.[25][26] Aquatic formulations using the isopropylamine salt of glyphosate include Glypro (also called Rodeo, Aquapro, and Accord Concentrate)[27] and Shore-Klear.[28] Refuge is also approved for aquatic applications; the active ingredient in this formulation is the potassium salt of glyphosate.[28][29] There are a few aquatic formulations that already include a surfactant that are registered for aquatic applications including GlyphoMate41 and Shore-Klear Plus, but most aquatic formulations do not include surfactant. The composition of surfactants is proprietary and non-disclosed, but low-toxicity surfactants that are labeled for aquatic use are available.[30][26]

Legal

On 10 August 2018, Dewayne "Lee" Johnson, who has non-Hodgkin's lymphoma, was awarded $289 million in damages in the case Johnson v. Monsanto Co. (later cut to $78 million on appeal[1] then reduced to $21 million after another appeal[2]) after a jury in San Francisco found that Monsanto had failed to adequately warn consumers of cancer risks posed by the herbicide.[31][32] Johnson had routinely used two different glyphosate formulations in his work as a groundskeeper, RoundUp and another Monsanto product called Ranger Pro.[33][34] The jury's verdict addressed the question of whether Monsanto knowingly failed to warn consumers that RoundUp could be harmful, but not whether RoundUp causes cancer.[35] Court documents from the case show the company's efforts to influence scientific research via ghostwriting.[36] After the IARC classified glyphosate as a "probably carcinogenic to humans"[37] in 2015, over 300 federal lawsuits have been filed that were consolidated into a multidistrict litigation called In re: RoundUp Products Liability.[38]

In March 2019, a man was awarded $80 million in a lawsuit claiming Roundup was a substantial factor in his cancer,[39][40] resulting in Costco stores discontinuing sales.[41] In July 2019, U.S. District Judge Vince Chhabria reduced the settlement to $26 million.[42] Chhabria stated that a punative award was appropriate because the evidence "easily supported a conclusion that Monsanto was more concerned with tamping down safety inquiries and manipulating public opinion than it was with ensuring its product is safe." Chhabria stated that there is evidence is on both sides concerning whether glyphosate causes cancer and that the behavior of Monsanto showed "a lack of concern about the risk that its product might be carcinogenic."[42]

On 13 May 2019 a jury in California ordered Bayer to pay a couple $2 billion in damages after finding that the company had failed to adequately inform consumers of the possible carcinogenicity of Roundup.[43] On July 26, 2019, an Alameda County judge cut the settlement to $86.7 million, stating that the judgement by the jury exceeded legal precedent.[44]

In June 2020, Bayer agreed to settle over a hundred thousand Roundup lawsuits, agreeing to pay $8.8 to $9.6 billion to settle those claims, and $1.5 billion for any future claims. The settlement does not include three cases that have already gone to jury trials and are being appealed.[45]

Acute toxicity

Further information: Chemistry:The dose makes the poison

The lethal dose of different glyphosate-based formulations varies, especially with respect to the surfactants used. Formulations intended for terrestrial use that include the surfactant polyethoxylated tallow amine (POEA) can be more toxic than other formulations for aquatic species.[46][47] Due to the variety in available formulations, including five different glyphosate salts and different combinations of inert ingredients, it is difficult to determine how much surfactants contribute to the overall toxicity of each formulation.[18][48] Independent scientific reviews and regulatory agencies have regularly concluded that glyphosate-based herbicides do not lead to a significant risk for human or environmental health when the product label is properly followed.[49]

Human

The acute oral toxicity for mammals is low,[46] but death has been reported after deliberate overdose of concentrated formulations.[50] The surfactants in glyphosate formulations can increase the relative acute toxicity of the formulation.[48][18] Surfactants generally do not, however, cause synergistic effects (as opposed to additive effects) that increase the acute toxicity of glyphosate within a formulation.[48] The surfactant POEA is not considered an acute toxicity hazard, and has an oral toxicity similar to vitamin A and less toxic than aspirin.[51] Deliberate ingestion of Roundup ranging from 85 to 200 ml (of 41% solution) has resulted in death within hours of ingestion, although it has also been ingested in quantities as large as 500 ml with only mild or moderate symptoms.[52] Consumption of over 85 ml of concentrated product causes serious symptoms, including burns due to corrosive effects as well as kidney and liver damage.

Forest visitors and nearby residents could be exposed to herbicide drift, vegetation with herbicide residues, and to accidental spraying. They also could eat food or drink water containing herbicide residues.[16]

In a 2017 risk assessment, the European Chemicals Agency (ECHA) wrote: "There is very limited information on skin irritation in humans. Where skin irritation has been reported, it is unclear whether it is related to glyphosate or co-formulants in glyphosate-containing herbicide formulations." The ECHA concluded that available human data was insufficient to support classification for skin corrosion or irritation.[53]

Inhalation is typically less harmful, though mist particles can result in irritation within the mouth or nostrils. Minor conjunctivitis can occur from eye exposure, and damage to the cornea can develop if the eye is not thoroughly rinsed after exposure.[48]

Aquatic

Glyphosate products for aquatic use generally do not use surfactants, and formulations with POEA are not approved for aquatic use due to aquatic organism toxicity.[26] Due to the presence of POEA, glyphosate formulations only allowed for terrestrial use are more toxic for amphibians and fish than glyphosate alone.[26][54][55] Terrestrial glyphosate formulations that include the surfactants POEA and MON 0818 (75% POEA) may have negative impacts on various aquatic organisms like protozoa, mussels, crustaceans, frogs and fish.[46] Aquatic organism exposure risk to terrestrial formulations with POEA may occur due to drift, agricultural runoff[56] or temporary water pockets.[26] While laboratory studies can show effects of glyphosate formulations on aquatic organisms, similar observations rarely occur in the field when instructions on the herbicide label are followed.[49]

Studies in a variety of amphibians have shown the toxicity of GBFs containing POEA to amphibian larvae. These effects include interference with gill morphology and mortality from either the loss of osmotic stability or asphyxiation. At sub-lethal concentrations, exposure to POEA or glyphosate/POEA formulations has been associated with delayed development, accelerated development, reduced size at metamorphosis, developmental malformations of the tail, mouth, eye and head, histological indications of intersex and symptoms of oxidative stress.[55] Glyphosate-based formulations can cause oxidative stress in bullfrog tadpoles.[37] The use of glyphosate-based pesticides are not considered the major cause of amphibian decline, the bulk of which occurred prior to widespread use of glyphosate or in pristine tropical areas with minimal glyphosate exposure.[57]

Mammals

Pure chemical grade glyphosate is slightly toxic to birds and is virtually nontoxic to fish, aquatic invertebrates and honeybees. However, commercial herbicide formulations consist of combinations of glyphosate salts, adjuvants and surfactants, and are not tested as such prior to regulatory approval. Due to the presence of a toxic inert ingredient, some glyphosate end-use products must be labeled, "Toxic to fish," if they may be applied directly to aquatic environments.[58] In mammals, most glyphosate is excreted, unchanged, in urine and feces. In rats, Glyphosate was not broken down given in oral doses, and it did not bioaccumulate.[58]

Sub-lethal effects

Most regulatory studies require only short-term exposure to high levels of the regulated substance, and do not investigate the effects of long-term exposure to sub-lethal levels. There is now increasing concern that chronic exposure to sub-lethal levels of glyphosate based herbicides may be having severe effects on ecosystem,[59][60][61][62] animal[63] and human[64][65][66] health, especially when considering the possibility of synergistic effects with other chemicals also present in the environment.[67][68]

Laboratory animal research reveals potential impacts on reproduction,[63] carcinogenesis[69] and even multigenerational[63] and transgenerational [70] effects ,due to epigenetic changes. Trangenerational studies[63][70] showed dramatic effects on fertility, neurological development, prostate disease, obesity, kidney disease, ovarian disease, and parturition (birth) abnormalities in the grand offspring (F2) and great-grand-offspring (F3) of mothers exposed to glyphosate.

Biomonitoring studies suggest that humans in a non-agricultural setting may be exposed to glyphosate through drinking water[71] and by eating products derived from crops contaminated with this herbicide, especially as glyphosate has been shown to accumulate in plant tissues to levels much higher than present in the environment.[72] Significant glyphosate residues have been detected in multiple crops, including honey,[73] corn, wheat and soy products.[74][75][76]

A 2018 study in central Indiana found that > 90% of pregnant women had detectable urinary glyphosate levels and that these levels correlated significantly with shortened pregnancy lengths.[77]

Glyphosate exposure has also been implicated as a contributing factor in the development of chronic kidney disease in agricultural workers.[78][79]

Carcinogenicity of active ingredient

There is limited evidence human cancer risk might increase as a result of occupational exposure to large amounts of glyphosate, such as agricultural work, but no good evidence of such a risk from home use, such as in domestic gardening.[80] The consensus among national pesticide regulatory agencies and scientific organizations is that labeled uses of glyphosate have demonstrated no evidence of human carcinogenicity.[81] Organizations such as the Joint FAO/WHO Meeting on Pesticide Residues, European Commission, Canadian Pest Management Regulatory Agency, and the German Federal Institute for Risk Assessment[82] have concluded that there is no evidence that glyphosate poses a carcinogenic or genotoxic risk to humans.[citation needed] The final assessment of the Australian Pesticides and Veterinary Medicines Authority in 2017 was that "glyphosate does not pose a carcinogenic risk to humans".[83] In a draft document the EPA has classified glyphosate as "not likely to be carcinogenic to humans."[84] One international scientific organization, the International Agency for Research on Cancer (IARC), affiliated with the WHO, has made claims of carcinogenicity in research reviews; in 2015 the IARC declared glyphosate "probably carcinogenic to humans."[85][37]

Environmental impact

Due to the widespread cultivation of crop species designed to withstand herbicide application, a move towards no-till agriculture, and weeds developing glyphosate resistance, increasing amounts of glyphosate-based herbicides are now required for weed control globally.[86] This widespread and increasing use is leading to the detection of glyphosate in surface waters, sediment and soil across South America,[87][88][89] North America,[90] Europe,[91][92] Asia[93] and Africa,[94] sometimes at levels above regulatory limits. However, regulatory limits vary immensely across jurisdictions. For example, maximum allowable drinking water levels in Europe are set at 100 ng/L[91] while the Environmental Protection Agency in the USA allows up to 700 ug/L glyphosate in American drinking water, while in many countries allowable levels of glyphosate in the environment and drinking water are not regulated at all.

In crops and other plants, there is evidence that glyphosate exposure can lead to increased susceptibility to disease, especially fungal root rot, and changes in mineral nutrition.[66][95]

On a wider front, there is the added concern that the widespread agricultural use of glyphosate may be contributing to antibiotic resistance and changes in soil and other microbiomes, as this herbicide is known to act as an antibiotic and affects microbial and fungal communities.[96][97]

As mentioned before, glyphosate-based herbicides can be harmful to freshwater and marine aquatic life, affecting invertebrates,[98][99] amphibians and fish[100] especially in their juvenile life stages. Lately, research has focused on what happens when organisms are exposed to low levels of herbicide over longer time periods, at levels detected during environmental monitoring. The results suggest a level of concern is warranted - exposure to environmentally realistic levels of glyphosate based herbicides (10 ug/L to 20 ug/L) have been shown to negatively affect blood parameters of the mussel Mytilus galloprovincialis and the clam Ruditapes philippinarum,[99] as well as decreasing reproduction and growth of the estuarine crab Neohelice granulata.[101][102]

Glyphosate based herbicides may be leading to overgrowth of blue-green algae in freshwater bodies,[103] while levels as low as 1 ug/L can lead to total loss of recruitment in the canopy forming marine macroalga, Carpodesmia crinita[104] potentially leading to population collapse. Glyphosate exposure can also alter the structure of natural freshwater bacterial and zooplankton communities. Researchers found that for zooplankton, aquatic concentrations of 0.1 mg/L glyphosate were sufficient to cause diversity loss.[105] These effects on organisms at the base of the food chain may have long term unintended effects.

Glyphosate is also being detected in wildlife, with long term effects unknown. For example a study published in 2021 detected glyphosate in 55% of sampled Florida manatees’ plasma, with blood levels increasing significantly from 2009 until 2019. In the same study, glyphosate was ubiquitous in surface water samples.[106]

Supply chain issues

Between January and November 2021, the price of glyphosate rose 25 percent due to the effects of the 2021–2022 global supply chain crisis and COVID-19. In February 2022, Bayer AG announced they would be declaring a force majeure following a mechanical failure and production shutdown at a key supplier. Shortages were expected to lead to increased costs for cotton, soybean and corn producers.[107]

References

  1. ↑ 1.0 1.1 "Groundskeeper Accepts Reduced $78 Million Award In Monsanto Cancer Suit". NPR. https://www.npr.org/2018/11/01/662812333/groundskeeper-accepts-reduced-78-million-in-monsanto-cancer-suit. 
  2. ↑ 2.0 2.1 "Award to Vallejo groundskeeper in Monsanto cancer case slashed again – verdict upheld". San Francisco Chronicle. 21 July 2020. https://www.sfchronicle.com/bayarea/article/Award-to-Vallejo-groundskeeper-in-Monsanto-cancer-15421705.php. 
  3. ↑ "Monsanto ordered to pay $289 million to man who claims Roundup weed killer caused cancer". abc.net.au. AP (Australian Broadcasting Corporation). 11 August 2018. http://www.abc.net.au/news/2018-08-11/monsanto-ordered-to-pay-289-million-to-school-groundskeeper/10109352. 
  4. ↑ 4.0 4.1 "Glyphosate General Fact Sheet". National Pesticide Information Center. September 2010. http://npic.orst.edu/factsheets/glyphogen.html. 
  5. ↑ "The history and current status of glyphosate". Pest Management Science 74 (5): 1027–1034. May 2018. doi:10.1002/ps.4652. PMID 28643882. https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=2784&context=usdaarsfacpub. 
  6. ↑ "Top-selling herbicide not close to withering". Wall Street Journal. 1996-01-08. https://www.newspapers.com/clip/22746669/topselling_herbicide_not_close_to/. 
  7. ↑ 7.0 7.1 "What Do We Really Know About Roundup Weed Killer?". National Geographic News. 2015-04-23. https://news.nationalgeographic.com/2015/04/150422-glyphosate-roundup-herbicide-weeds/. 
  8. ↑ "Monsanto No More: Agri-Chemical Giant's Name Dropped In Bayer Acquisition". NPR.org. https://www.npr.org/sections/thetwo-way/2018/06/04/616772911/monsanto-no-more-agri-chemical-giants-name-dropped-in-bayer-acquisition. 
  9. ↑ "Does This Common Pesticide Cause Cancer?". WebMD. https://www.webmd.com/cancer/news/20150407/glyphosate-pesticide-probable-carcinogen. 
  10. ↑ "Ecotoxicological effects of different glyphosate formulations". Applied Soil Ecology 72: 215–224. 2013-10-01. doi:10.1016/j.apsoil.2013.07.005. ISSN 0929-1393. 
  11. ↑ "Glyphosate Market for Genetically Modified and Conventional Crops – Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 – 2019". Research and Markets. February 2014. http://www.researchandmarkets.com:80/research/wjnh3q/glyphosate_market. 
  12. ↑ "Unidentified inert ingredients in pesticides: implications for human and environmental health". Environmental Health Perspectives 114 (12): 1803–1806. December 2006. doi:10.1289/ehp.9374. PMID 17185266. 
  13. ↑ "Glyphosate Formulations". Control Methods Handbook, Chapter 8, Adjuvants: Weekly Crop Update. University of Delaware Cooperative Extension. http://agdev.anr.udel.edu/weeklycropupdate/?p=96. 
  14. ↑ "Glyphosate". Weed Control Methods Handbook. The Nature Conservancy. 2003-06-01. http://www.invasive.org/gist/products/handbook/14.Glyphosate.pdf. 
  15. ↑ "Adjuvants for Enhancing Herbicide Performance". Penn State Extension. 1999. http://extension.psu.edu/pests/weeds/control/adjuvants-for-enhancing-herbicide-performance. 
  16. ↑ 16.0 16.1 "Glyphosate: Herbicide Information Profile". USDA Forest Service. February 1997. https://www.fs.usda.gov/Internet/FSE_DOCUMENTS/fsbdev2_025810.pdf. 
  17. ↑ Analysis of Issues Surrounding the Use of Spray Adjuvants With Herbicides (Report). pp. 61. https://www.fs.usda.gov/Internet/FSE_DOCUMENTS/fsbdev3_045552.pdf. 
  18. ↑ 18.0 18.1 18.2 Glyphosate: Human Health and Ecological Risk Assessment (Report). Syracuse Environmental Research Associates, Inc.(SERA). 1 March 2003. https://www.fs.fed.us/r5/hfqlg/publications/herbicide_info/2003_glyphosate.pdf. Retrieved 2018-08-20. 
  19. ↑ "Renewal Assessment Report: Glyphosate. Volume 1. Report and Proposed Decision.". German Institute for Risk Assessment: 64–65. 18 December 2013. http://dar.efsa.europa.eu/dar-web/provision.  (registration required)
  20. ↑ Pesticide Policy and Politics in the European Union: Regulatory Assessment, Implementation and Enforcement. Springer. 2017-03-23. pp. 85–86. ISBN 978-3-319-52736-9. 
  21. ↑ "Glyphosate – Food Safety – European Commission". Food Safety. https://ec.europa.eu/food/plant/pesticides/glyphosate_en. 
  22. ↑ "EPA Approves Dow's Enlist Herbicide for GMOs". Scientific American. https://www.scientificamerican.com/article/epa-approves-dow-s-enlist-herbicide-for-gmos/. 
  23. ↑ "Busted: EPA Discovers Dow Weedkiller Claim, Wants It Off The Market". NPR.org. https://www.npr.org/sections/thesalt/2015/11/25/457393114/busted-epa-discovers-dow-weedkiller-claim-wants-it-off-the-market. 
  24. ↑ 24.0 24.1 "Court clears way for revival of worrisome weedkiller". chicagotribune.com. http://www.chicagotribune.com/news/watchdog/ct-dow-enlist-duo-court-ruling-20160127-story.html. 
  25. ↑ "Pesticides and Aquatic Animals: A Guide to Reducing Impacts on Aquatic Systems" (in en). Virginia Cooperative Extension. https://pubs.ext.vt.edu/420/420-013/420-013.html. 
  26. ↑ 26.0 26.1 26.2 26.3 26.4 "SS-AGR-104 Safe Use of Glyphosate-Containing Products in Aquatic and Upland Natural Areas". University of Florida. https://edis.ifas.ufl.edu/pdffiles/AG/AG24800.pdf. 
  27. ↑ "Glypro Herbicide EPA 2015 product label". U.S. Environmental Protection Agency. 20 August 2015. http://www3.epa.gov/pesticides/chem_search/ppls/062719-00324-20150820.pdf. 
  28. ↑ 28.0 28.1 "Glyphosate Chemical Fact Sheet". Wisconsin Department of Natural Resources. https://dnr.wi.gov/lakes/plants/factsheets/GlyphosateFactsheet.pdf. 
  29. ↑ "Refuge Herbicide EPA 2011 product label". U.S. Environmental Protection Agency. https://www3.epa.gov/pesticides/chem_search/ppls/000100-01362-20111021.pdf. 
  30. ↑ "Identifying and Managing Aquatic Vegetation". Aquatic Plant Management (Purdue University Botany): 19. https://mdc.itap.purdue.edu/item.asp?itemID=18924. 
  31. ↑ "Monsanto ordered to pay $289 million in world's first Roundup...". Reuters. 2018-08-11. https://www.reuters.com/article/us-monsanto-cancer-lawsuit/jury-orders-monsanto-to-pay-290-million-in-california-roundup-cancer-trial-idUSKBN1KV2HB. 
  32. ↑ "Weedkiller 'doesn't cause cancer' – Bayer" (in en-GB). BBC News. 2018-08-11. https://www.bbc.com/news/world-us-canada-45154362. 
  33. ↑ "Dying cancer patient awarded $395m in Monsanto Roundup case". The Sydney Morning Herald. 2018-08-11. https://www.smh.com.au/world/north-america/dying-cancer-patient-awarded-a395m-in-monsanto-roundup-case-20180811-p4zwww.html. 
  34. ↑ "Degree Xtra Herbicide (Reformat and Revise Based on Atrazine MOA)". Washington, D.C.: United States Environmental Protection Agency. November 18, 2004. https://www3.epa.gov/pesticides/chem_search/ppls/000524-00511-20041118.pdf. 
  35. ↑ "Monsanto Just Lost a Case Linking Its Weed Killer to Cancer". The Nation. 2018-08-17. ISSN 0027-8378. https://www.thenation.com/article/monsanto-just-lost-a-case-linking-its-weedkiller-to-cancer/. 
  36. ↑ "Monsanto Emails Raise Issue of Influencing Research on Roundup Weed Killer" (in en). NY Times. 2018-08-01. https://www.nytimes.com/2017/08/01/business/monsantos-sway-over-research-is-seen-in-disclosed-emails.html. 
  37. ↑ 37.0 37.1 37.2 "Glyphosate". IARC Monographs on the Evaluation of Carcinogenic Risks to Humans (International Agency for Research on Cancer) 112. 11 August 2016. https://monographs.iarc.fr/wp-content/uploads/2018/06/mono112-10.pdf. Retrieved July 31, 2019. 
  38. ↑ "Monsanto's Cancer Fight Judge Pictures Weed Killer Showers". Bloomberg.com. 2018-03-14. https://www.bloomberg.com/news/articles/2018-03-14/monsanto-judge-pictures-weed-killer-showers-amid-cancer-debate. 
  39. ↑ "Jury Awards $80 Million In Damages In Roundup Weed Killer Cancer Trial". NPR. 2019-03-29. https://www.npr.org/2019/03/27/707439575/jury-awards-80-million-in-damages-in-roundup-weed-killer-cancer-trial. 
  40. ↑ "Louisville lawyer wins $80M verdict against Monsanto over weedkiller Roundup". The Courier-Journal (Louisville, Kentucky). 2019-03-28. https://www.courier-journal.com/story/news/2019/03/28/monsanto-roundup-cancer-lawsuit-louisville-lawyer-wins-huge-verdict-80-million/3295421002/. 
  41. ↑ "Costco stops selling controversial Roundup weedkiller" (in en). Big Think. 29 March 2019. https://bigthink.com/politics-current-affairs/roundup-costco. 
  42. ↑ 42.0 42.1 "Judge Reduces $80M Award In Roundup Case; Cancer Patient, Monsanto Both Consider Appeal". KPIX-TV. Associated Press (San Francisco). 2019-07-15. https://sanfrancisco.cbslocal.com/2019/07/15/80-million-award-reduced-monsanto-roundup-cancer-patient/. 
  43. ↑ "Bayer's $2 Billion Roundup Damages Boost Pressure to Settle". bloomberg.com. 13 May 2019. https://www.bloomberg.com/news/articles/2019-05-13/bayer-loses-its-third-trial-over-claims-roundup-causes-cancer. 
  44. ↑ "Judge cuts $2 billion award for couple with cancer to $86.7 million in Roundup lawsuit". Washington Post. 2019-07-26. https://www.washingtonpost.com/business/2019/07/26/judge-cuts-billion-award-couple-with-cancer-million-roundup-lawsuit. 
  45. ↑ "Bayer To Pay More Than $10 Billion To Resolve Cancer Lawsuits Over Weedkiller Roundup". June 24, 2020. https://www.npr.org/2020/06/24/882949098/bayer-to-pay-more-than-10-billion-to-resolve-roundup-cancer-lawsuits. 
  46. ↑ 46.0 46.1 46.2 "Environmental and health effects of the herbicide glyphosate". The Science of the Total Environment 616-617: 255–268. March 2018. doi:10.1016/j.scitotenv.2017.10.309. PMID 29117584. Bibcode: 2018ScTEn.616..255V. 
  47. ↑ Effects of Surfactants on the Toxicity of Glyphosate, with Specific Reference to Rodeo, Syracuse Environmental Research Associates, Inc. (SERA), https://www.fs.fed.us/r5/hfqlg/publications/herbicide_info/2003_glyphosate.pdf, retrieved 2018-08-20 
  48. ↑ 48.0 48.1 48.2 48.3 "Glyphosate poisoning". Toxicological Reviews 23 (3): 159–167. 2004. doi:10.2165/00139709-200423030-00003. PMID 15862083. 
  49. ↑ 49.0 49.1 "The Risks Associated with Glyphosate-Based Herbicide Use in Planted Forests". Forests 8 (6): 208. 12 June 2017. doi:10.3390/f8060208. 
  50. ↑ "Pathological and toxicological findings in glyphosate-surfactant herbicide fatality: a case report". The American Journal of Forensic Medicine and Pathology 33 (3): 234–237. September 2012. doi:10.1097/PAF.0b013e31824b936c. PMID 22835958. 
  51. ↑ "Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans". Regulatory Toxicology and Pharmacology 31 (2 Pt 1): 117–165. April 2000. doi:10.1006/rtph.1999.1371. PMID 10854122. 
  52. ↑ "Acute poisoning with a glyphosate-surfactant herbicide ('Roundup'): a review of 93 cases". Human & Experimental Toxicology 10 (1): 1–8. January 1991. doi:10.1177/096032719101000101. PMID 1673618. 
  53. ↑ "Committee of Risk Assessment Opinion proposing harmonised classification and labelling at EU level of glyphosate (ISO); N-(phosphonomethyl)glycine". European Chemicals Agency. 15 March 2017. https://echa.europa.eu/documents/10162/2f8b5c7f-030f-5d3a-e87e-0262fb392f38. 
  54. ↑ Gary L. Diamond and Patrick R. Durkin February 6, 1997, under contract from the United States Department of Agriculture. Effects of Surfactants on the Toxicity of Glyphosate, with Specific Reference to RODEO
  55. ↑ 55.0 55.1 "Amphibians and agricultural chemicals: review of the risks in a complex environment". Environmental Pollution 157 (11): 2903–2927. November 2009. doi:10.1016/j.envpol.2009.05.015. PMID 19500891. http://hdl.cqu.edu.au/10018/35613. 
  56. ↑ "Glyphosate, aminomethylphosphonic acid, and glufosinate ammonium in agricultural groundwater and surface water in China from 2017 to 2018: Occurrence, main drivers, and environmental risk assessment". The Science of the Total Environment 769: 144396. May 2021. doi:10.1016/j.scitotenv.2020.144396. PMID 33486182. Bibcode: 2021ScTEn.769n4396G. 
  57. ↑ "Questions concerning the potential impact of glyphosate-based herbicides on amphibians". Environmental Toxicology and Chemistry 32 (8): 1688–1700. August 2013. doi:10.1002/etc.2268. PMID 23637092. 
  58. ↑ 58.0 58.1 "Fact sheet for Glyphosate". United States Environmental Protection Agency. https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-417300_1-Sep-93.pdf. 
  59. ↑ "Glyphosate-based herbicide exposure affects diatom community development in natural biofilms". Environmental Pollution 284: 117354. September 2021. doi:10.1016/j.envpol.2021.117354. PMID 34030084. 
  60. ↑ "Potential toxic effects of glyphosate and its commercial formulations below regulatory limits". Food and Chemical Toxicology 84: 133–153. October 2015. doi:10.1016/j.fct.2015.08.012. PMID 26282372. https://kclpure.kcl.ac.uk/portal/en/publications/potential-toxic-effects-of-glyphosate-and-its-commercial-formulations-below-regulatory-limits(e185bac2-4db2-4568-b1d2-f258ed2fe7f3).html. 
  61. ↑ "The effects of glyphosate-based herbicide formulations on Lemna minor, a non-target species". Aquatic Toxicology 209: 70–80. April 2019. doi:10.1016/j.aquatox.2019.01.021. PMID 30739875. 
  62. ↑ "The Effects of Glyphosate and Its Commercial Formulations to Marine Invertebrates: A Review" (in en). Journal of Marine Science and Engineering 8 (6): 399. 2020-06-01. doi:10.3390/jmse8060399. ISSN 2077-1312. 
  63. ↑ 63.0 63.1 63.2 63.3 "Glyphosate Herbicide: Reproductive Outcomes and Multigenerational Effects". Frontiers in Endocrinology 12: 672532. 2021-07-07. doi:10.3389/fendo.2021.672532. PMID 34305812. 
  64. ↑ "Co-Formulants in Glyphosate-Based Herbicides Disrupt Aromatase Activity in Human Cells below Toxic Levels". International Journal of Environmental Research and Public Health 13 (3): 264. February 2016. doi:10.3390/ijerph13030264. PMID 26927151. 
  65. ↑ "The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity". Journal of Immunotoxicology 17 (1): 163–174. December 2020. doi:10.1080/1547691X.2020.1804492. PMID 32897110. 
  66. ↑ 66.0 66.1 "Indirect Effects of the Herbicide Glyphosate on Plant, Animal and Human Health Through its Effects on Microbial Communities". Frontiers in Environmental Science 9: 763917. 2021-10-18. doi:10.3389/fenvs.2021.763917. ISSN 2296-665X. 
  67. ↑ European Environment Agency. (2018). Chemicals in European waters: knowledge developments.. LU: Publications Office. doi:10.2800/265080. ISBN 9789294800060. https://data.europa.eu/doi/10.2800/265080. 
  68. ↑ "Can pesticides, copper and seasonal water temperature explain the seagrass Zostera noltei decline in the Arcachon bay?". Marine Pollution Bulletin 134: 66–74. September 2018. doi:10.1016/j.marpolbul.2017.10.024. PMID 29106936. https://archimer.ifremer.fr/doc/00407/51831/. 
  69. ↑ "Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate". The Lancet. Oncology 16 (5): 490–491. May 2015. doi:10.1016/S1470-2045(15)70134-8. PMID 25801782. 
  70. ↑ 70.0 70.1 "Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology". Scientific Reports 9 (1): 6372. April 2019. doi:10.1038/s41598-019-42860-0. PMID 31011160. Bibcode: 2019NatSR...9.6372K. 
  71. ↑ "Glyphosate Residues in Groundwater, Drinking Water and Urine of Subsistence Farmers from Intensive Agriculture Localities: A Survey in Hopelchén, Campeche, Mexico". International Journal of Environmental Research and Public Health 14 (6): 595. June 2017. doi:10.3390/ijerph14060595. PMID 28587206. 
  72. ↑ "Glyphosate: Its Environmental Persistence and Impact on Crop Health and Nutrition". Plants 8 (11): 499. November 2019. doi:10.3390/plants8110499. PMID 31766148. 
  73. ↑ "Glyphosate residue concentrations in honey attributed through geospatial analysis to proximity of large-scale agriculture and transfer off-site by bees". PLOS ONE 13 (7): e0198876. 2018-07-11. doi:10.1371/journal.pone.0198876. PMID 29995880. Bibcode: 2018PLoSO..1398876B. 
  74. ↑ "Occurrence of glyphosate and AMPA residues in soy-based infant formula sold in Brazil". Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 35 (4): 723–730. April 2018. doi:10.1080/19440049.2017.1419286. PMID 29267136. 
  75. ↑ "Compositional differences in soybeans on the market: glyphosate accumulates in Roundup Ready GM soybeans". Food Chemistry 153: 207–215. June 2014. doi:10.1016/j.foodchem.2013.12.054. PMID 24491722. 
  76. ↑ "Glyphosate Use, Toxicity and Occurrence in Food". Foods 10 (11): 2785. November 2021. doi:10.3390/foods10112785. PMID 34829065. 
  77. ↑ "Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study". Environmental Health 17 (1): 23. March 2018. doi:10.1186/s12940-018-0367-0. PMID 29519238. 
  78. ↑ "The Effect of Co-Exposure to Glyphosate, Cadmium, and Arsenic on Chronic Kidney Disease" (in en). Exposure and Health 14 (3): 779–789. 2022-09-01. doi:10.1007/s12403-021-00451-3. ISSN 2451-9685. https://doi.org/10.1007/s12403-021-00451-3. 
  79. ↑ "Activation of the N-methyl-d-aspartate receptor is involved in glyphosate-induced renal proximal tubule cell apoptosis". Journal of Applied Toxicology 39 (8): 1096–1107. August 2019. doi:10.1002/jat.3795. PMID 30907447. 
  80. ↑ "Food Controversies—Pesticides and organic foods". Cancer Research UK. 2016. http://www.cancerresearchuk.org/about-cancer/causes-of-cancer/diet-and-cancer/food-controversies#food_controversies4. 
  81. ↑ "Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC". Archives of Toxicology 91 (8): 2723–2743. August 2017. doi:10.1007/s00204-017-1962-5. PMID 28374158. 
  82. ↑ "The BfR has finalised its draft report for the re-evaluation of glyphosate". German Federal Institute for Risk Assessment (BfR). https://www.bfr.bund.de/en/the_bfr_has_finalised_its_draft_report_for_the_re_evaluation_of_glyphosate-188632.html. 
  83. ↑ "Australian Pesticides and Veterinary Medicines Authority". Encyclopedia of Nanoscience and Society. Thousand Oaks, CA: SAGE Publications, Inc.. 2010. pp. 38–39. doi:10.4135/9781412972093. ISBN 978-1-4129-6987-1. http://sk.sagepub.com/reference/nanoscience/n22.xml. 
  84. ↑ US EPA, OCSPP (2017-12-18). "EPA Releases Draft Risk Assessments for Glyphosate" (Announcements and Schedules). US EPA. https://www.epa.gov/pesticides/epa-releases-draft-risk-assessments-glyphosate. 
  85. ↑ "Widely used herbicide linked to cancer". Nature. March 24, 2015. doi:10.1038/nature.2015.17181. https://www.nature.com/news/widely-used-herbicide-linked-to-cancer-1.17181. Retrieved April 1, 2019. 
  86. ↑ "PEST-CHEMGRIDS, global gridded maps of the top 20 crop-specific pesticide application rates from 2015 to 2025". Scientific Data 6 (1): 170. September 2019. doi:10.1038/s41597-019-0169-4. PMID 31515508. Bibcode: 2019NatSD...6..170M. 
  87. ↑ "Levels of glyphosate in surface waters, sediments and soils associated with direct sowing soybean cultivation in north pampasic region of Argentina". Environmental Pollution 156 (1): 61–66. November 2008. doi:10.1016/j.envpol.2008.01.015. PMID 18308436. 
  88. ↑ "The Fate of Glyphosate and AMPA in a Freshwater Endorheic Basin: An Ecotoxicological Risk Assessment". Toxics 6 (1): 3. December 2017. doi:10.3390/toxics6010003. PMID 29267202. 
  89. ↑ "Glyphosate and AMPA, "pseudo-persistent" pollutants under real-world agricultural management practices in the Mesopotamic Pampas agroecosystem, Argentina". Environmental Pollution 229: 771–779. October 2017. doi:10.1016/j.envpol.2017.06.006. PMID 28693752. http://sedici.unlp.edu.ar/handle/10915/154724. 
  90. ↑ "Glyphosate and Its Degradation Product AMPA Occur Frequently and Widely in U.S. Soils, Surface Water, Groundwater, and Precipitation" (in en). JAWRA Journal of the American Water Resources Association 50 (2): 275–290. 2014. doi:10.1111/jawr.12159. Bibcode: 2014JAWRA..50..275B. https://onlinelibrary.wiley.com/doi/10.1111/jawr.12159. 
  91. ↑ 91.0 91.1 "Glyphosate and AMPA in the estuaries of the Baltic Sea method optimization and field study". Marine Pollution Bulletin 100 (1): 577–585. November 2015. doi:10.1016/j.marpolbul.2015.08.015. PMID 26342388. 
  92. ↑ "Direct and indirect effects of the herbicides Glyphosate, Bentazone and MCPA on eelgrass (Zostera marina)". Aquatic Toxicology 82 (1): 47–54. April 2007. doi:10.1016/j.aquatox.2007.01.004. PMID 17328972. 
  93. ↑ "Glyphosate, aminomethylphosphonic acid, and glufosinate ammonium in agricultural groundwater and surface water in China from 2017 to 2018: Occurrence, main drivers, and environmental risk assessment". The Science of the Total Environment 769: 144396. May 2021. doi:10.1016/j.scitotenv.2020.144396. PMID 33486182. Bibcode: 2021ScTEn.769n4396G. 
  94. ↑ "A first assessment of glyphosate, 2,4-D and Cry proteins in surface water of South Africa". South African Journal of Science 115 (9/10). 2019-09-26. doi:10.17159/sajs.2019/5988. ISSN 1996-7489. https://sajs.co.za/article/view/5988. 
  95. ↑ "Glyphosate effects on plant mineral nutrition, crop rhizosphere microbiota, and plant disease in glyphosate-resistant crops". Journal of Agricultural and Food Chemistry 60 (42): 10375–10397. October 2012. doi:10.1021/jf302436u. PMID 23013354. 
  96. ↑ "Role of glyphosate in the emergence of antimicrobial resistance in bacteria?". The Journal of Antimicrobial Chemotherapy 76 (7): 1655–1657. June 2021. doi:10.1093/jac/dkab102. PMID 33893490. 
  97. ↑ "A Glyphosate-Based Herbicide Cross-Selects for Antibiotic Resistance Genes in Bacterioplankton Communities". mSystems 7 (2): e0148221. April 2022. doi:10.1128/msystems.01482-21. PMID 35266795. 
  98. ↑ "Impact of glyphosate and glyphosate-based herbicides on the freshwater environment". Journal of Applied Toxicology 34 (5): 458–479. May 2014. doi:10.1002/jat.2997. PMID 24615870. 
  99. ↑ 99.0 99.1 "The Effects of Glyphosate and Its Commercial Formulations to Marine Invertebrates: A Review" (in en). Journal of Marine Science and Engineering 8 (6): 399. 2020. doi:10.3390/jmse8060399. ISSN 2077-1312. 
  100. ↑ "Mutagenicity and genotoxicity in juvenile African catfish, Clarias gariepinus exposed to formulations of glyphosate and paraquat". Science Progress 104 (2): 368504211021751. 2021. doi:10.1177/00368504211021751. PMID 34148463. 
  101. ↑ "Ovarian growth impairment after chronic exposure to Roundup Ultramax® in the estuarine crab Neohelice granulata". Environmental Science and Pollution Research International 25 (2): 1568–1575. January 2018. doi:10.1007/s11356-017-0581-2. PMID 29098583. 
  102. ↑ "Effects of Glyphosate on Somatic and Ovarian Growth in the Estuarine Crab Neohelice granulata, During the Pre-Reproductive Period" (in en). Water, Air, & Soil Pollution 229 (2): 44. 2018-01-25. doi:10.1007/s11270-018-3698-0. ISSN 1573-2932. Bibcode: 2018WASP..229...44A. https://doi.org/10.1007/s11270-018-3698-0. 
  103. ↑ "Glyphosate dose modulates the uptake of inorganic phosphate by freshwater cyanobacteria". Journal of Applied Phycology 30 (1): 299–309. 2018-02-01. doi:10.1007/s10811-017-1231-2. PMID 29576687. 
  104. ↑ "Differential effects of pollution on adult and recruits of a canopy-forming alga: implications for population viability under low pollutant levels". Scientific Reports 10 (1): 17825. October 2020. doi:10.1038/s41598-020-73990-5. PMID 33082390. Bibcode: 2020NatSR..1017825D. 
  105. ↑ "Widespread agrochemicals differentially affect zooplankton biomass and community structure". Ecological Applications 31 (7): e02423. October 2021. doi:10.1002/eap.2423. PMID 34288209. 
  106. ↑ "Chronic exposure to glyphosate in Florida manatee". Environment International 152: 106493. July 2021. doi:10.1016/j.envint.2021.106493. PMID 33740675. 
  107. ↑ "Cost of Growing Food to Rise Even More Amid Weedkiller Supply Crunch". Bloomberg News. 2022-02-15. https://www.bloomberg.com/news/articles/2022-02-15/farmers-costs-to-grow-food-rise-amid-roundup-supply-crunch. 



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