Biology:HACL1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
2-hydroxyacyl-CoA lyase 1 is a protein that in humans is encoded by the HACL1 gene. It produces a 2-Hydroxyphytanoyl-CoA lyase.[1]
Function
The product is a peroxisomal enzyme involved in the catabolism of phytanoic acid by α-oxidation. It requires thiamine diphosphate (ThDP) as cofactor.[2]
The corresponding EC number is 4.1.2.63.
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References
- ↑ "Entrez Gene: 2-hydroxyacyl-CoA lyase 1". https://www.ncbi.nlm.nih.gov/gene/26061.
- ↑ "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. 1999. doi:10.1073/pnas.96.18.10039. PMID 10468558. Bibcode: 1999PNAS...9610039F.
Further reading
- "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. 1999. doi:10.1073/pnas.96.18.10039. PMID 10468558. Bibcode: 1999PNAS...9610039F.
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