Biology:HAP2
From HandWiki
| Male gamete fusion factor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | HAP2-GCS1 | ||||||||
| Pfam | PF10699 | ||||||||
| InterPro | IPR018928 | ||||||||
| |||||||||
HAP2 (hapless 2), also known as GCS1 (generative cell-specific protein 1), is a family of membrane fusion proteins found in the sperm cell of diverse eukaryotes including Toxoplasma, thale cress, and fruit flies. This protein is essential for gamete fusion, and therefore fertilization, in these organisms. It is a domesticated instance of a viral class II fusion protein.[1]
References
- ↑ "The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein". Cell 168 (5): 904–915.e10. February 2017. doi:10.1016/j.cell.2017.01.024. PMID 28235200.
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