Biology:HIST1H3F
![]() Generic protein structure example |
Histone H3.1 is a protein that in humans is encoded by the HIST1H3F gene.[1][2][3]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[3]
References
- ↑ "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. Apr 1997. doi:10.1006/geno.1996.4592. PMID 9119399.
- ↑ "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. Oct 2002. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
- ↑ 3.0 3.1 "Entrez Gene: HIST1H3F histone cluster 1, H3f". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8968.
Further reading
- "Isolation and characterization of two human H1 histone genes within clusters of core histone genes.". Genomics 10 (4): 940–8. 1991. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
- "The human histone gene cluster at the D6S105 locus.". Hum. Genet. 101 (3): 284–94. 1998. doi:10.1007/s004390050630. PMID 9439656.
- "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.". Mol. Cell. Biol. 18 (5): 2535–44. 1998. doi:10.1128/mcb.18.5.2535. PMID 9566873.
- "Regulation of chromatin structure by site-specific histone H3 methyltransferases.". Nature 406 (6796): 593–9. 2000. doi:10.1038/35020506. PMID 10949293. Bibcode: 2000Natur.406..593R.
- "Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.". Cell 102 (3): 279–91. 2000. doi:10.1016/S0092-8674(00)00034-9. PMID 10975519.
- "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.". Virology 277 (2): 278–95. 2001. doi:10.1006/viro.2000.0593. PMID 11080476.
- "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.". Nature 410 (6824): 116–20. 2001. doi:10.1038/35065132. PMID 11242053. Bibcode: 2001Natur.410..116L.
- "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.". Virology 289 (2): 312–26. 2001. doi:10.1006/viro.2001.1129. PMID 11689053.
- "Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.". Oncogene 21 (1): 148–52. 2002. doi:10.1038/sj.onc.1204998. PMID 11791185.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Structure and catalytic mechanism of the human histone methyltransferase SET7/9.". Nature 421 (6923): 652–6. 2003. doi:10.1038/nature01378. PMID 12540855. Bibcode: 2003Natur.421..652X. http://eprints.whiterose.ac.uk/111/1/blackburngm1.pdf.
- "Aberrant expression pattern of replication-dependent histone h3 subtype genes in human tumor cell lines.". DNA Cell Biol. 22 (4): 233–41. 2003. doi:10.1089/104454903321908629. PMID 12823900.
- "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.". EMBO J. 22 (24): 6550–61. 2004. doi:10.1093/emboj/cdg631. PMID 14657027.
- "Structural basis for the methylation site specificity of SET7/9.". Nat. Struct. Mol. Biol. 13 (2): 140–6. 2006. doi:10.1038/nsmb1045. PMID 16415881.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.