Biology:HIST1H3F

Generic protein structure example

Histone H3.1 is a protein that in humans is encoded by the HIST1H3F gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

Further reading

• "Isolation and characterization of two human H1 histone genes within clusters of core histone genes.". Genomics 10 (4): 940–8. 1991. doi:10.1016/0888-7543(91)90183-F. PMID 1916825. 
• "The human histone gene cluster at the D6S105 locus.". Hum. Genet. 101 (3): 284–94. 1998. doi:10.1007/s004390050630. PMID 9439656. 
• "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.". Mol. Cell. Biol. 18 (5): 2535–44. 1998. doi:10.1128/mcb.18.5.2535. PMID 9566873. 
• "Regulation of chromatin structure by site-specific histone H3 methyltransferases.". Nature 406 (6796): 593–9. 2000. doi:10.1038/35020506. PMID 10949293. Bibcode: 2000Natur.406..593R. 
• "Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.". Cell 102 (3): 279–91. 2000. doi:10.1016/S0092-8674(00)00034-9. PMID 10975519. 
• "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.". Virology 277 (2): 278–95. 2001. doi:10.1006/viro.2000.0593. PMID 11080476. 
• "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.". Nature 410 (6824): 116–20. 2001. doi:10.1038/35065132. PMID 11242053. Bibcode: 2001Natur.410..116L. 
• "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.". Virology 289 (2): 312–26. 2001. doi:10.1006/viro.2001.1129. PMID 11689053. 
• "Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.". Oncogene 21 (1): 148–52. 2002. doi:10.1038/sj.onc.1204998. PMID 11791185. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Structure and catalytic mechanism of the human histone methyltransferase SET7/9.". Nature 421 (6923): 652–6. 2003. doi:10.1038/nature01378. PMID 12540855. Bibcode: 2003Natur.421..652X. http://eprints.whiterose.ac.uk/111/1/blackburngm1.pdf. 
• "Aberrant expression pattern of replication-dependent histone h3 subtype genes in human tumor cell lines.". DNA Cell Biol. 22 (4): 233–41. 2003. doi:10.1089/104454903321908629. PMID 12823900. 
• "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.". EMBO J. 22 (24): 6550–61. 2004. doi:10.1093/emboj/cdg631. PMID 14657027. 
• "Structural basis for the methylation site specificity of SET7/9.". Nat. Struct. Mol. Biol. 13 (2): 140–6. 2006. doi:10.1038/nsmb1045. PMID 16415881. 
• "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.