Biology:HIST1H4B

Histone H4 is a protein that in humans is encoded by the HIST1H4B gene.^[1]^[2]^[3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 147 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[3]

References

↑ "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–322. Apr 1997. doi:10.1006/geno.1996.4592. PMID 9119399.
↑ "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–498. Oct 2002. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
↑ ^3.0 ^3.1 "Entrez Gene: HIST1H4B histone cluster 1, H4b". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8366.

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