Biology:HIST1H4L

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Histone H4 is a protein that in humans is encoded by the HIST1H4L gene.[1][2][3][4]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[4]

References

  1. "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene 184 (2): 141–8. Mar 1997. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620. 
  2. "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. Feb 1998. doi:10.1007/s004390050630. PMID 9439656. 
  3. "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. Oct 2002. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. 4.0 4.1 "Entrez Gene: HIST1H4L histone cluster 1, H4l". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8368. 

Further reading