Biology:Histoplasma
| Histoplasma | |
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| Tuberculate macroconidia of Histoplasma capsulatum | |
Scientific classification 
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| Domain: | Eukaryota |
| Kingdom: | Fungi |
| Division: | Ascomycota |
| Class: | Eurotiomycetes |
| Order: | Onygenales |
| Family: | Ajellomycetaceae |
| Genus: | Histoplasma Darling (1906) |
| Type species | |
| Histoplasma capsulatum Darling (1906)
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| Species | |
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Histoplasma capsulatum | |
Histoplasma is a genus of fungi in the order Onygenales.[1] Species are known human pathogens producing yeast-like states under pathogenic conditions. They are the causative agents of histoplasmosis in humans and epizootic lymphangitis in horses.[2]
Forms / Stages
Histoplasma species have two forms: their environmental form is hyphal with microconidia and tuberculate macroconidia while their pathogenic form is a small intracellular yeast with a narrow neck and no bud with no capsule.[3] Infection occurs through inhalation of microconidia or small mycelial fragments. The dimorphic mold-yeast transforms and enters host macrophages and proliferates within them. Infections are most often seen in immunodeficient individuals.[4]
Species are mainly found in the Ohio and Mississippi River Valleys in the United States (H.ohiense and H. mississippiense) as well as Central (H. capsulatum) and South America (H. suramericanum), Africa (H. duboisii), Asia, and Australia.[5][6]
References
- ↑ "Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis". Fungal Diversity 90: 245–291. 2018. doi:10.1007/s13225-018-0403-y.
- ↑ OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2004 Chapter 2.5.13, "Archived copy". Archived from the original on 2007-08-04. https://web.archive.org/web/20070804182644/http://www.oie.int/eng/normes/MMANUAL/A_00091.htm. Retrieved 2007-06-14.
- ↑ Hutton, JP (April 1985). "Hyphal forms of Histoplasma capsulatum. A common manifestation of intravascular infections". Archives of Pathology and Laboratory Medicine 109 (4): 330–332. PMID 3885898. https://pubmed.ncbi.nlm.nih.gov/3885898/.
- ↑ Lopez, CE (Oct 2006). "Dimorphism and pathogenesis of Histoplasma capsulatum". Revista Argentina de Microbiologia 38 (4): 235–242. PMID 17370580. https://pubmed.ncbi.nlm.nih.gov/17370580/.
- ↑ "Histoplasmosis". 28 October 2020. https://www.cdc.gov/fungal/diseases/histoplasmosis/index.html.
- ↑ "Genome sequences reveal cryptic speciation in the human pathogen Histoplasma capsulatum". mBio 8 (6). 2017. doi:10.1128/mbio.01339-17. PMC 5717386. https://journals.asm.org/doi/10.1128/mbio.01339-17.
Wikidata ☰ Q10941019 entry
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