Biology:Human Biomolecular Atlas Program

From HandWiki
3 branches of HuBMAP: transformative technology development, the tissue mapping center and the HuBMAP integration, visualization and engagement.[1]

The Human Biomolecular Atlas Program (HuBMAP) is a program funded by the US National Institutes of Health to characterize the human body at single cell resolution, integrated to other efforts such as the Human Cell Atlas.[1] Among the products of the program is the Azimuth reference datasets for single-cell RNA seq data [2][3] and the ASCT+B Reporter, a visualization tool for anatomical structures, cell types and biomarkers.[4][5]

Millitomes are used to create uniformly sized tissue blocks that match the shape and size of organs from HuBMAP's 3D Reference Object Library.[6]

The HuBMAP received 27 million US dollars of funding from the NIH in 2020 and about 28.5 million in 2021.[7]

Technologies and approaches used by the HuBMAP consortium, including single-cell RNA sequencing and spatial trancriptomics.[1]

References

  1. ↑ 1.0 1.1 1.2 "The human body at cellular resolution: the NIH Human Biomolecular Atlas Program" (in English). Nature 574 (7777): 187–192. October 2019. doi:10.1038/S41586-019-1629-X. PMID 31597973. Bibcode: 2019Natur.574..187H. 
  2. ↑ "Integrated analysis of multimodal single-cell data". Cell 184 (13): 3573–3587.e29. June 2021. doi:10.1016/j.cell.2021.04.048. PMID 34062119. 
  3. ↑ "Azimuth" (in en-us). https://azimuth.hubmapconsortium.org/. 
  4. ↑ "ASCT+B Reporter" (in en). https://ccf-asctb-reporter-v2.netlify.app/. 
  5. ↑ "Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature". bioRxiv. 2022-03-01. doi:10.1101/2022.02.28.482302. 
  6. ↑ HIVE MC-IU Team. "HuBMAP: CCF Portal" (in en). https://hubmapconsortium.github.io/ccf/pages/ccf-3d-reference-library.html. 
  7. ↑ "NIH Common Fund CONGRESSIONAL JUSTIFICATION FY 2022". https://commonfund.nih.gov/sites/default/files/Common-Fund-FY-2022-CJ-508.pdf. 

External links




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