Biology:Hydrogen dehydrogenase (NADP+)

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hydrogen dehydrogenase (NADP+)
Identifiers
EC number1.12.1.3
CAS number9027-05-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a hydrogen dehydrogenase (NADP+) (EC 1.12.1.3) is an enzyme that catalyzes the chemical reaction

H2 + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] H+ + NADPH

Thus, the two substrates of this enzyme are H2 and NADP+, whereas its two products are H+ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NADP+ oxidoreductase. Other names in common use include NADP+-linked hydrogenase, NADP+-reducing hydrogenase, hydrogen dehydrogenase (NADP+), and simply hydrogenase (which is ambiguous).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2AUV.

References

  • "The NADP-reducing hydrogenase of Desulfovibrio fructosovorans: evidence for a native complex with hydrogen-dependent methyl-viologen-reducing activity". Biochem. Biophys. Res. Commun. 248 (3): 591–6. 1998. doi:10.1006/bbrc.1998.9022. PMID 9703971.