Biology:IGBP1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the IGBP1 gene.[1][2]
Function
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.[2]
Interactions
IGBP1 has been shown to interact with PPP4C,[3][4][5] PPP6C[4][5] and PPP2CA.[4][5][6][7]
References
- ↑ "Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway". Genomics 46 (3): 373–8. Dec 1997. doi:10.1006/geno.1997.5048. PMID 9441740.
- ↑ 2.0 2.1 "Entrez Gene: IGBP1 immunoglobulin (CD79A) binding protein 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3476.
- ↑ "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry 283 (43): 29273–84. Oct 2008. doi:10.1074/jbc.M803443200. PMID 18715871.
- ↑ 4.0 4.1 4.2 "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics 4 (11): 1725–40. Nov 2005. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
- ↑ 5.0 5.1 5.2 "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications 247 (3): 827–32. Jun 1998. doi:10.1006/bbrc.1998.8792. PMID 9647778. Bibcode: 1998BBRC..247..827C.
- ↑ "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics 8 (1): 157–71. Jan 2009. doi:10.1074/mcp.M800266-MCP200. PMID 18782753.
- ↑ "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry 38 (32): 10371–6. Aug 1999. doi:10.1021/bi990902g. PMID 10441131.
Further reading
- "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications 247 (3): 827–32. Jun 1998. doi:10.1006/bbrc.1998.8792. PMID 9647778. Bibcode: 1998BBRC..247..827C.
- "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry 38 (32): 10371–6. Aug 1999. doi:10.1021/bi990902g. PMID 10441131.
- "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer 83 (4): 456–64. Nov 1999. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- "Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4". Proceedings of the National Academy of Sciences of the United States of America 98 (12): 6650–5. Jun 2001. doi:10.1073/pnas.111154698. PMID 11371618. Bibcode: 2001PNAS...98.6650L.
- "MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders". BMC Cell Biology 3. 2002. doi:10.1186/1471-2121-3-1. PMID 11806752.
- "A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13". American Journal of Medical Genetics Part A 123A (1): 37–44. Nov 2003. doi:10.1002/ajmg.a.20504. PMID 14556245.
- "Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1764 (4): 724–34. Apr 2006. doi:10.1016/j.bbapap.2006.01.018. PMID 16517231.
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