Biology:INPPL1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene.

INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.

Interactions

INPPL1 has been shown to interact with:

• BCAR1,
• FLNC,
• SHC1, and
• SORBS1.

Further reading

• "Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP.". Biochem. Biophys. Res. Commun. 239 (3): 697–700. 1997. doi:10.1006/bbrc.1997.7538. PMID 9367831. 
• "Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein.". J. Biol. Chem. 273 (29): 18605–9. 1998. doi:10.1074/jbc.273.29.18605. PMID 9660833. 
• "The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity.". FEBS Lett. 437 (3): 301–3. 1998. doi:10.1016/S0014-5793(98)01255-1. PMID 9824312. 
• "A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.". Blood 93 (8): 2707–20. 1999. doi:10.1182/blood.V93.8.2707. PMID 10194451. 
• "The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes.". Biol. Chem. 380 (7–8): 969–74. 1999. doi:10.1515/BC.1999.120. PMID 10494849. 
• "The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse.". Genomics 62 (2): 260–71. 2000. doi:10.1006/geno.1999.5995. PMID 10610720. 
• "The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling.". Immunol. Lett. 72 (1): 7–15. 2000. doi:10.1016/S0165-2478(00)00162-0. PMID 10789675. 
• "SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading.". Mol. Cell. Biol. 21 (4): 1416–28. 2001. doi:10.1128/MCB.21.4.1416-1428.2001. PMID 11158326. 
• "Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.". Mol. Cell. Biol. 21 (5): 1633–46. 2001. doi:10.1128/MCB.21.5.1633-1646.2001. PMID 11238900. 
• "The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.". J. Biol. Chem. 276 (30): 28348–55. 2001. doi:10.1074/jbc.M103537200. PMID 11349134. 
• "The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.". J. Cell Biol. 155 (6): 1065–79. 2002. doi:10.1083/jcb.200104005. PMID 11739414. 
• "The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.". Diabetes 51 (7): 2012–7. 2002. doi:10.2337/diabetes.51.7.2012. PMID 12086927. 
• "SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line.". Biochem. Biophys. Res. Commun. 296 (1): 106–10. 2002. doi:10.1016/S0006-291X(02)00787-8. PMID 12147234. 
• "Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I.". J. Cell Sci. 115 (Pt 19): 3807–15. 2003. doi:10.1242/jcs.00070. PMID 12235291. 
• "Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells.". J. Immunol. 169 (8): 4370–8. 2002. doi:10.4049/jimmunol.169.8.4370. PMID 12370370. 
• "The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.". Biochem. Biophys. Res. Commun. 300 (2): 494–500. 2003. doi:10.1016/S0006-291X(02)02894-2. PMID 12504111. 
• "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. 2003. doi:10.1073/pnas.2436191100. PMID 12522270. Bibcode: 2003PNAS..100..443S. 
• "SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling.". J. Biol. Chem. 278 (25): 22657–63. 2003. doi:10.1074/jbc.M302907200. PMID 12690104. 
• "Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.". Diabetes 53 (7): 1900–4. 2004. doi:10.2337/diabetes.53.7.1900. PMID 15220217. 
• "Mutation Altering the miR-184 Seed Region Causes Familial Keratoconus with Cataract". The American Journal of Human Genetics 89 (5): 628–33. 2011. doi:10.1016/j.ajhg.2011.09.014. PMID 21996275.