Biology:IRAK2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.[1][2]
Function
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.[2]
Interactions
IRAK2 has been shown to interact with TRAF6[1][3] and Myd88.[1][3][4]
References
- ↑ 1.0 1.1 1.2 "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science 278 (5343): 1612–5. Nov 1997. doi:10.1126/science.278.5343.1612. PMID 9374458. Bibcode: 1997Sci...278.1612M.
- ↑ 2.0 2.1 "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3656.
- ↑ 3.0 3.1 "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry 274 (27): 19403–10. Jul 1999. doi:10.1074/jbc.274.27.19403. PMID 10383454.
- ↑ "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature 413 (6851): 78–83. Sep 2001. doi:10.1038/35092578. PMID 11544529. Bibcode: 2001Natur.413...78F.
Further reading
- "The interleukin 1 receptor: ligand interactions and signal transduction". Cytokine & Growth Factor Reviews 9 (3–4): 221–37. 1999. doi:10.1016/S1359-6101(98)00018-5. PMID 9918122.
- "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB". The Biochemical Journal 339 ( Pt 2) (2): 227–31. Apr 1999. doi:10.1042/0264-6021:3390227. PMID 10191251.
- "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry 274 (27): 19403–10. Jul 1999. doi:10.1074/jbc.274.27.19403. PMID 10383454.
- "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature 413 (6851): 78–83. Sep 2001. doi:10.1038/35092578. PMID 11544529. Bibcode: 2001Natur.413...78F.
- "Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1". The Journal of Biological Chemistry 277 (10): 7808–15. Mar 2002. doi:10.1074/jbc.M108133200. PMID 11744690.
- "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry 278 (9): 7607–16. Feb 2003. doi:10.1074/jbc.M210455200. PMID 12493773.
- "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry 278 (27): 24526–32. Jul 2003. doi:10.1074/jbc.M303451200. PMID 12721283.
- "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter". Journal of Molecular Biology 346 (2): 411–22. Feb 2005. doi:10.1016/j.jmb.2004.11.066. PMID 15670593.
- "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination". The Journal of Biological Chemistry 282 (46): 33435–43. Nov 2007. doi:10.1074/jbc.M705266200. PMID 17878161.
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